(R*)-4-allyl-1-benzyl-4-(2,3-dimethoxyphenyl)-1,2,3,4-tetrahydropyridine

Base Information

Chemical Name:(R*)-4-allyl-1-benzyl-4-(2,3-dimethoxyphenyl)-1,2,3,4-tetrahydropyridine
CAS No.:1308331-18-1
Molecular Formula:C₂₃H₂₇NO₂
Molecular Weight:349.473
Hs Code.:

Synonyms:(R*)-4-allyl-1-benzyl-4-(2,3-dimethoxyphenyl)-1,2,3,4-tetrahydropyridine

Suppliers and Price of (R*)-4-allyl-1-benzyl-4-(2,3-dimethoxyphenyl)-1,2,3,4-tetrahydropyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R*)-4-allyl-1-benzyl-4-(2,3-dimethoxyphenyl)-1,2,3,4-tetrahydropyridine

Chemical Property:

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Technology Process of (R*)-4-allyl-1-benzyl-4-(2,3-dimethoxyphenyl)-1,2,3,4-tetrahydropyridine

There total 4 articles about (R*)-4-allyl-1-benzyl-4-(2,3-dimethoxyphenyl)-1,2,3,4-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1308331-15-8
1-benzyl-4-(2,3-dimethoxyphenyl)-1,2,3,6-tetrahydropyridine

: 106-95-6
allyl bromide

: 1308331-18-1
(R*)-4-allyl-1-benzyl-4-(2,3-dimethoxyphenyl)-1,2,3,4-tetrahydropyridine

Guidance literature:: 1-benzyl-4-(2,3-dimethoxyphenyl)-1,2,3,6-tetrahydropyridine; With sec.-butyllithium; In tetrahydrofuran; cyclohexane; at -50 - -20 ℃;

allyl bromide; In tetrahydrofuran; cyclohexane; at -50 - 20 ℃;
DOI:10.1021/jm800913d

Reference yield:

: 1308331-14-7
1-benzyl-4-(2,3-dimethoxyphenyl)piperidin-4-ol

: 1308331-18-1
(R*)-4-allyl-1-benzyl-4-(2,3-dimethoxyphenyl)-1,2,3,4-tetrahydropyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / toluene / 18 h / Reflux

2.1: sec.-butyllithium / tetrahydrofuran; cyclohexane / -50 °C

2.2: -50 - 20 °C

With sec.-butyllithium; toluene-4-sulfonic acid; In tetrahydrofuran; cyclohexane; toluene;
DOI:10.1016/j.bmc.2011.04.028

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 1308331-18-1
(R*)-4-allyl-1-benzyl-4-(2,3-dimethoxyphenyl)-1,2,3,4-tetrahydropyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / diethyl ether / 19.5 h / 20 °C / Cooling with ice; Inert atmosphere

1.2: 0 °C / Inert atmosphere

1.3: Inert atmosphere

2.1: toluene-4-sulfonic acid / toluene / 18 h / Reflux

3.1: sec.-butyllithium / tetrahydrofuran; cyclohexane / -50 °C

3.2: -50 - 20 °C

With n-butyllithium; sec.-butyllithium; toluene-4-sulfonic acid; In tetrahydrofuran; diethyl ether; cyclohexane; toluene;
DOI:10.1016/j.bmc.2011.04.028