O-benzyl-N^a-(9-fluorenylmethoxycarbonyl)-N^im-(triphenylmethyl)-(S)-erythro-3-hydroxyhistidine

Base Information

• Chemical Name: O-benzyl-N^a-(9-fluorenylmethoxycarbonyl)-N^im-(triphenylmethyl)-(S)-erythro-3-hydroxyhistidine
• CAS No.: 477335-39-0
• Molecular Formula: C₄₇H₃₉N₃O₅
• Molecular Weight: 725.844

Synonyms:O-benzyl-N^a-(9-fluorenylmethoxycarbonyl)-N^im-(triphenylmethyl)-(S)-erythro-3-hydroxyhistidine

Chemical Property of O-benzyl-N^a-(9-fluorenylmethoxycarbonyl)-N^im-(triphenylmethyl)-(S)-erythro-3-hydroxyhistidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O-benzyl-N^a-(9-fluorenylmethoxycarbonyl)-N^im-(triphenylmethyl)-(S)-erythro-3-hydroxyhistidine

There total 1 articles about O-benzyl-N^a-(9-fluorenylmethoxycarbonyl)-N^im-(triphenylmethyl)-(S)-erythro-3-hydroxyhistidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

benzylamine (100-46-9) + Na-(9-fluorenylmethoxycarbonyl)-Nim-(triphenylmethyl)-(S)-erythro-3-hydroxyhistidine (308849-84-5) → O-benzyl-Na-(9-fluorenylmethoxycarbonyl)-Nim-(triphenylmethyl)-(S)-erythro-3-hydroxyhistidine (477335-39-0)

Guidance literature:

In ethyl acetate; at 20 ℃; for 3h;

DOI:10.1021/ja0208916

Reference yield: 63.3%

O-benzyl-Na-(9-fluorenylmethoxycarbonyl)-Nim-(triphenylmethyl)-(S)-erythro-3-hydroxyhistidine (477335-39-0) + Acetic acid (2S,3R,4S,5S,6R)-3-acetoxy-2-acetoxymethyl-5-((2R,3S,4S,5R,6R)-3,5-diacetoxy-6-acetoxymethyl-4-carbamoyloxy-tetrahydro-pyran-2-yloxy)-6-(diphenoxy-phosphoryl)-tetrahydro-pyran-4-yl ester → erythro-Na-(9-fluorenylmethoxycarbonyl)-3-O-[3,4,6-tri-O-acetyl-2-O-(2,4,6-tri-O-acetyl-3-O-carbomoyl-α-D-mannopyranosyl)-α-L-gulopyranosyl]-Nim-(triphenylmethyl)-S-histidine benzyl ester

Guidance literature:

O-benzyl-N^a-(9-fluorenylmethoxycarbonyl)-N^im-(triphenylmethyl)-(S)-erythro-3-hydroxyhistidine; Acetic acid (2S,3R,4S,5S,6R)-3-acetoxy-2-acetoxymethyl-5-((2R,3S,4S,5R,6R)-3,5-diacetoxy-6-acetoxymethyl-4-carbamoyloxy-tetrahydro-pyran-2-yloxy)-6-(diphenoxy-phosphoryl)-tetrahydro-pyran-4-yl ester; In chloroform; for 0.0833333h;

With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -50 ℃; Further stages.;

DOI:10.1021/ja0208916

Reference yield:

O-benzyl-Na-(9-fluorenylmethoxycarbonyl)-Nim-(triphenylmethyl)-(S)-erythro-3-hydroxyhistidine (477335-39-0) → erythro-Na-(9-fluorenylmethoxycarbonyl)-3-O'-[3,4,6-tri-O-acetyl-2-O-(2,4,6-O-acetyl-3-O-carbamoyl-α-D-mannopyranosyl)-α-L-gulopyranosyl]-Nim-(triphenylmethyl)-S-histidine

Guidance literature:

Multi-step reaction with 2 steps

1.1: CHCl₃ / 0.08 h

1.2: 63.3 percent / trimethylsilyltriflate / CH₂Cl₂ / -50 °C

2.1: 49 percent / aq. NaHCO₃; H₂ / Pearlman's catalyst / methanol / 2 h / 20 °C

With hydrogen; sodium hydrogencarbonate; palladium dihydroxide; In methanol; chloroform;

DOI:10.1021/ja0208916

upstream raw materials:

benzylamine

N^a-(9-fluorenylmethoxycarbonyl)-N^im-(triphenylmethyl)-(S)-erythro-3-hydroxyhistidine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 477335-39-0 O-benzyl-N^a-(9-fluorenylmethoxycarbonyl)-N^im-(triphenylmethyl)-(S)-erythro-3-hydroxyhistidine

Send

Send

Metric Ton KG G Pound L ML

Send

Send