tert-butyl {4'-[3-(4(S)-benzyl-2-oxo-oxazolidin-3-yl)-2(S)ethoxy-1(R)-hydroxy-3-oxopropyl]-biphenyl-3-yl}methylcarbamate

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Chemical Name:tert-butyl {4'-[3-(4(S)-benzyl-2-oxo-oxazolidin-3-yl)-2(S)ethoxy-1(R)-hydroxy-3-oxopropyl]-biphenyl-3-yl}methylcarbamate
CAS No.:869089-98-5
Molecular Formula:C₃₃H₃₈N₂O₇
Molecular Weight:574.674
Hs Code.:

Synonyms:tert-butyl {4'-[3-(4(S)-benzyl-2-oxo-oxazolidin-3-yl)-2(S)ethoxy-1(R)-hydroxy-3-oxopropyl]-biphenyl-3-yl}methylcarbamate

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Chemical Property of tert-butyl {4'-[3-(4(S)-benzyl-2-oxo-oxazolidin-3-yl)-2(S)ethoxy-1(R)-hydroxy-3-oxopropyl]-biphenyl-3-yl}methylcarbamate

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Technology Process of tert-butyl {4'-[3-(4(S)-benzyl-2-oxo-oxazolidin-3-yl)-2(S)ethoxy-1(R)-hydroxy-3-oxopropyl]-biphenyl-3-yl}methylcarbamate

There total 5 articles about tert-butyl {4'-[3-(4(S)-benzyl-2-oxo-oxazolidin-3-yl)-2(S)ethoxy-1(R)-hydroxy-3-oxopropyl]-biphenyl-3-yl}methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 561013-61-4
tert-butyl (4'-formylbiphenyl-3-yl)methylcarbamate

: 869089-98-5
tert-butyl {4'-[3-(4(S)-benzyl-2-oxo-oxazolidin-3-yl)-2(S)ethoxy-1(R)-hydroxy-3-oxopropyl]-biphenyl-3-yl}methylcarbamate

Guidance literature:: (S)-4-benzyl-3-(2-ethoxy-ethanoyl)-oxazolidin-2-one; With di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.5h;

tert-butyl (4'-formylbiphenyl-3-yl)methylcarbamate; In dichloromethane; at -78 - 20 ℃; for 4h;

Reference yield:

: 57598-34-2
3-Bromo-N-tert-butoxycarbonyl-N-methylaniline

: 869089-98-5
tert-butyl {4'-[3-(4(S)-benzyl-2-oxo-oxazolidin-3-yl)-2(S)ethoxy-1(R)-hydroxy-3-oxopropyl]-biphenyl-3-yl}methylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 24 h / 90 °C

2.1: di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C

2.2: 4 h / -78 - 20 °C

With di-n-butylboryl trifluoromethanesulfonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; water; toluene;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 869089-98-5
tert-butyl {4'-[3-(4(S)-benzyl-2-oxo-oxazolidin-3-yl)-2(S)ethoxy-1(R)-hydroxy-3-oxopropyl]-biphenyl-3-yl}methylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane / 18 h / 20 °C

2.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 18 h

3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 24 h / 90 °C

4.1: di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C

4.2: 4 h / -78 - 20 °C

With di-n-butylboryl trifluoromethanesulfonate; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In DMF (N,N-dimethyl-formamide); dichloromethane; water; toluene;