trans-(+/-)-1-Methyl-4-(N-phenylpropanamido)-piperidine-2-carboxamide

Base Information

• Chemical Name: trans-(+/-)-1-Methyl-4-(N-phenylpropanamido)-piperidine-2-carboxamide
• CAS No.: 85893-44-3
• Molecular Formula: C₁₆H₂₃N₃O₂
• Molecular Weight: 289.378
• Mol file: 85893-44-3.mol

Synonyms:trans-(+/-)-1-Methyl-4-(N-phenylpropanamido)-piperidine-2-carboxamide

Chemical Property of trans-(+/-)-1-Methyl-4-(N-phenylpropanamido)-piperidine-2-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-(+/-)-1-Methyl-4-(N-phenylpropanamido)-piperidine-2-carboxamide

There total 2 articles about trans-(+/-)-1-Methyl-4-(N-phenylpropanamido)-piperidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

trans-(+/-)-N-(2-Cyano-1-methyl-4-piperidyl)-N-phenylpropanamide (85893-41-0) → trans-(+/-)-1-Methyl-4-(N-phenylpropanamido)-piperidine-2-carboxamide (85893-44-3)

Guidance literature:

With sulfuric acid; 1) 0-5 degC, 2h, 2) 25 degC, 48h;

DOI:10.1021/jo00161a004

Reference yield:

N-(1-Methyl-1-oxy-piperidin-4-yl)-N-phenyl-propionamide (85893-35-2) → trans-(+/-)-1-Methyl-4-(N-phenylpropanamido)-piperidine-2-carboxamide (85893-44-3)

Guidance literature:

Multi-step reaction with 2 steps

2: 79 percent / conc. sulfuric acid / 1) 0-5 degC, 2h, 2) 25 degC, 48h

With sulfuric acid;

DOI:10.1021/jo00161a004

Reference yield: 80.0%

trans-(+/-)-1-Methyl-4-(N-phenylpropanamido)-piperidine-2-carboxamide (85893-44-3) → cis-(+/-)-1-Methyl-4-(N-phenylpropanamido)-piperidine-2-carboxamide (85908-76-5)

Guidance literature:

With potassium hydroxide; In ethylene glycol; at 65 - 70 ℃; for 7h;

DOI:10.1021/jo00161a004

upstream raw materials:

trans-(+/-)-N-(2-Cyano-1-methyl-4-piperidyl)-N-phenylpropanamide

N-(1-Methyl-1-oxy-piperidin-4-yl)-N-phenyl-propionamide

Downstream raw materials:

cis-(+/-)-1-Methyl-4-(N-phenylpropanamido)-piperidine-2-carboxamide

trans-(+/-)-1-methyl-4-(N-phenylpropanamido)-piperidine-2-carboxylic acid hydrochloride

(2R,4R)-1-Methyl-4-(phenyl-propionyl-amino)-piperidine-2-carboxylic acid benzylamide