(E)-3-(1-(4-ethylphenethyl)-2-oxo-1,2-dihydropyridin-3-yl)-N-hydroxyacrylamide

Base Information

• Chemical Name: (E)-3-(1-(4-ethylphenethyl)-2-oxo-1,2-dihydropyridin-3-yl)-N-hydroxyacrylamide
• CAS No.: 1257335-98-0
• Molecular Formula: C₁₈H₂₀N₂O₃
• Molecular Weight: 312.368
• Mol file: 1257335-98-0.mol

Synonyms:(E)-3-(1-(4-ethylphenethyl)-2-oxo-1,2-dihydropyridin-3-yl)-N-hydroxyacrylamide

Chemical Property of (E)-3-(1-(4-ethylphenethyl)-2-oxo-1,2-dihydropyridin-3-yl)-N-hydroxyacrylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3-(1-(4-ethylphenethyl)-2-oxo-1,2-dihydropyridin-3-yl)-N-hydroxyacrylamide

There total 3 articles about (E)-3-(1-(4-ethylphenethyl)-2-oxo-1,2-dihydropyridin-3-yl)-N-hydroxyacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

(E)-methyl 3-(1-(4-ethylphenethyl)-2-oxo-1,2-dihydropyridin-3-yl)acrylate → (E)-3-(1-(4-ethylphenethyl)-2-oxo-1,2-dihydropyridin-3-yl)-N-hydroxyacrylamide (1257335-98-0)

Guidance literature:

With hydroxylamine potassium salt; In methanol; at 0 ℃; for 12h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.5b00062

Reference yield:

2-oxo-1,2-dihydro-pyridine-3-carbaldehyde (36404-89-4,32768-36-8) → (E)-3-(1-(4-ethylphenethyl)-2-oxo-1,2-dihydropyridin-3-yl)-N-hydroxyacrylamide (1257335-98-0)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloromethane / Reflux

2: potassium carbonate / acetone / Reflux

3: hydroxylamine potassium salt / methanol / 12 h / 0 °C / Inert atmosphere

With hydroxylamine potassium salt; potassium carbonate; In methanol; dichloromethane; acetone; 1: |Wittig Olefination;

DOI:10.1021/acs.jmedchem.5b00062

Reference yield:

4-ethyl-phenethyl bromide (259818-85-4) + [(E)-methyl 3-(2-oxo-1,2-dihydropyridin-3-yl)acrylate] → (E)-3-(1-(4-ethylphenethyl)-2-oxo-1,2-dihydropyridin-3-yl)-N-hydroxyacrylamide (1257335-98-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / Reflux

2: hydroxylamine potassium salt / methanol / 12 h / 0 °C / Inert atmosphere

With hydroxylamine potassium salt; potassium carbonate; In methanol; acetone;

DOI:10.1021/acs.jmedchem.5b00062

upstream raw materials:

2-oxo-1,2-dihydro-pyridine-3-carbaldehyde

4-ethyl-phenethyl bromide