Cyclopropanecarboxylic acid, 1-amino-2-methyl-, methyl ester (9CI)

Base Information

• Chemical Name: Cyclopropanecarboxylic acid, 1-amino-2-methyl-, methyl ester (9CI)
• CAS No.: 91366-09-5
• Molecular Formula: C₆H₁₁NO₂
• Molecular Weight: 129.159
• Mol file: 91366-09-5.mol

Synonyms:Cyclopropanecarboxylic acid, 1-amino-2-methyl-, methyl ester (9CI)

Chemical Property of Cyclopropanecarboxylic acid, 1-amino-2-methyl-, methyl ester (9CI)

Chemical Property:

• PSA: 52.32000
• LogP: 0.59700

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclopropanecarboxylic acid, 1-amino-2-methyl-, methyl ester (9CI)

There total 8 articles about Cyclopropanecarboxylic acid, 1-amino-2-methyl-, methyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methyl 1-methoxycarbonylamino-2-methylcyclopropane-1-carboxylate (91366-08-4) → methyl 1-amino-2-methylcyclopropane-1-carboxylate (91366-09-5,738554-17-1,690205-38-0,741649-07-0)

Guidance literature:

With trimethylsilyl iodide; In chloroform; at 50 - 60 ℃;

DOI:10.1021/ja00330a050

Reference yield:

diethyl 2-methylcyclopropane-1,1-dicarboxylate (16783-17-8) → methyl 1-amino-2-methylcyclopropane-1-carboxylate (91366-09-5,738554-17-1,690205-38-0,741649-07-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) sodium methoxide / 1.) ammonia, 5 days, rt

2: 35 percent / bromine / methanol / -45 - 55 °C

3: 85 percent / trimethylsilyliodide / CHCl₃ / 50 - 60 °C

With trimethylsilyl iodide; bromine; sodium methylate; In methanol; chloroform;

DOI:10.1021/ja00330a050

Reference yield:

1-methoxycarbonyl-2-methylcyclopropane-1-carboxamide (91366-07-3) → methyl 1-amino-2-methylcyclopropane-1-carboxylate (91366-09-5,738554-17-1,690205-38-0,741649-07-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 35 percent / bromine / methanol / -45 - 55 °C

2: 85 percent / trimethylsilyliodide / CHCl₃ / 50 - 60 °C

With trimethylsilyl iodide; bromine; In methanol; chloroform;

DOI:10.1021/ja00330a050

upstream raw materials:

methyl 1-methoxycarbonylamino-2-methylcyclopropane-1-carboxylate

diethyl 2-methylcyclopropane-1,1-dicarboxylate

1-methoxycarbonyl-2-methylcyclopropane-1-carboxamide

dimethyl 2-methyl-1,1-cyclopropanedicarboxylate