9-benzyloxy-6-(1-naphthalen-1-ylcyclopentylmethyl)-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione

Base Information

Chemical Name:9-benzyloxy-6-(1-naphthalen-1-ylcyclopentylmethyl)-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione
CAS No.:1616924-97-0
Molecular Formula:C₃₀H₂₉N₃O₃
Molecular Weight:479.579
Hs Code.:

Synonyms:9-benzyloxy-6-(1-naphthalen-1-ylcyclopentylmethyl)-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione

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Chemical Property of 9-benzyloxy-6-(1-naphthalen-1-ylcyclopentylmethyl)-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione

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Technology Process of 9-benzyloxy-6-(1-naphthalen-1-ylcyclopentylmethyl)-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione

There total 14 articles about 9-benzyloxy-6-(1-naphthalen-1-ylcyclopentylmethyl)-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616924-96-9
5-benzyloxy-6-hydroxy-2-(1-naphthalen-1-ylcyclopentylmethyl)pyrimidine-4-carboxylic acid (2-hydroxyethyl)amide

: 1616924-97-0
9-benzyloxy-6-(1-naphthalen-1-ylcyclopentylmethyl)-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In dichloromethane; at 20 ℃; for 0.25h;

Reference yield:

: 56477-61-3
1-naphthalen-1-ylcyclopentanecarbonitrile

: 1616924-97-0
9-benzyloxy-6-(1-naphthalen-1-ylcyclopentylmethyl)-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione

Guidance literature:: Multi-step reaction with 10 steps

1: diisobutylaluminium hydride / toluene; dichloromethane / 2 h / -78 °C

2: sodium tetrahydroborate; methanol / 1 h / 0 - 20 °C

3: triethylamine / dichloromethane / 18 h / 0 - 20 °C

4: potassium iodide / dimethyl sulfoxide / 2 h / 140 °C

5: ammonium chloride; trimethylaluminum / toluene / 18 h / 5 - 85 °C

6: sodium methylate / methanol / 18 h / 0 - 20 °C

7: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 h / Reflux

8: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1.5 h / 20 °C

9: hydrogenchloride / tetrahydrofuran; water / 1 h / 20 °C

10: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 0.25 h / 20 °C

With hydrogenchloride; methanol; sodium tetrahydroborate; lithium hydroxide monohydrate; di-isopropyl azodicarboxylate; trimethylaluminum; sodium methylate; diisobutylaluminium hydride; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; potassium iodide; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 2-(1-naphthalen-1-ylcyclopentyl)acetamidine hydrochloride

: 1616924-97-0
9-benzyloxy-6-(1-naphthalen-1-ylcyclopentylmethyl)-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione

Guidance literature:: Multi-step reaction with 5 steps

1: sodium methylate / methanol / 18 h / 0 - 20 °C

2: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 h / Reflux

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1.5 h / 20 °C

4: hydrogenchloride / tetrahydrofuran; water / 1 h / 20 °C

5: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 0.25 h / 20 °C

With hydrogenchloride; lithium hydroxide monohydrate; di-isopropyl azodicarboxylate; sodium methylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;