5-bromo-3-nitro-4-[4-(1-phenyl-ethyl)-piperazin-1-yl]-pyridin-2-ylamine

Base Information

• Chemical Name: 5-bromo-3-nitro-4-[4-(1-phenyl-ethyl)-piperazin-1-yl]-pyridin-2-ylamine
• CAS No.: 942949-20-4
• Molecular Formula: C₁₇H₂₀BrN₅O₂
• Molecular Weight: 406.282

Synonyms:5-bromo-3-nitro-4-[4-(1-phenyl-ethyl)-piperazin-1-yl]-pyridin-2-ylamine

Chemical Property of 5-bromo-3-nitro-4-[4-(1-phenyl-ethyl)-piperazin-1-yl]-pyridin-2-ylamine

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Technology Process of 5-bromo-3-nitro-4-[4-(1-phenyl-ethyl)-piperazin-1-yl]-pyridin-2-ylamine

There total 1 articles about 5-bromo-3-nitro-4-[4-(1-phenyl-ethyl)-piperazin-1-yl]-pyridin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

5-bromo-4-chloro-3-nitro-pyridin-2-ylamine (942947-95-7) + 1-phenylethyl piperazine (69628-75-7,759457-60-8) → 5-bromo-3-nitro-4-[4-(1-phenyl-ethyl)-piperazin-1-yl]-pyridin-2-ylamine (942949-20-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 45 ℃; for 20h;

Reference yield: 48.0%

5-bromo-3-nitro-4-[4-(1-phenyl-ethyl)-piperazin-1-yl]-pyridin-2-ylamine (942949-20-4) + 4-(4-(1,1-dimethylethoxycarbonyl)piperazinyl)benzaldehyde (197638-83-8) → tert-butyl 4-(4-(6-bromo-7-(4-(1-phenylethyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)phenyl)piperazine-1-carboxylate (1095381-56-8)

Guidance literature:

With sodium dithionite; In ethanol; water; at 80 ℃; for 20h;

Reference yield: 44.0%

5-bromo-3-nitro-4-[4-(1-phenyl-ethyl)-piperazin-1-yl]-pyridin-2-ylamine (942949-20-4) + tert-butyl N-(4-formylbenzyl)carbamate (156866-52-3) → tert-butyl 4-(6-bromo-7-(4-(1-phenylethyl)piperazin-1-yl)-3H-imidazo[4,5-d]pyridin-2-yl)benzylcarbamate

Guidance literature:

With sodium dithionite; In ethanol; water; at 80 ℃; for 18h;

upstream raw materials:

5-bromo-4-chloro-3-nitro-pyridin-2-ylamine

1-phenylethyl piperazine

Downstream raw materials:

tert-butyl 4-(4-(6-bromo-7-(4-(1-phenylethyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)phenyl)piperazine-1-carboxylate

2-(4-(6-bromo-7-(4-(1-phenylethyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy)ethanol

1-(4-{6-Bromo-7-[4-(1-phenyl-ethyl)-piperazin-1-yl]-3H-imidazo[4,5-b]pyridin-2-yl}-phenyl)-piperidin-4-ol

6-Bromo-2-(4-morpholin-4-ylmethyl-phenyl)-7-[4-(1-phenyl-ethyl)-piperazin-1-yl]-3H-imidazo[4,5-b]pyridine

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