ethyl 2,3,4,6-tetra-O-[(6-(6-maleimidohexanamido)-3-thia-hexyl)]-α-D-galactopyranoside

Base Information

• Chemical Name: ethyl 2,3,4,6-tetra-O-[(6-(6-maleimidohexanamido)-3-thia-hexyl)]-α-D-galactopyranoside
• CAS No.: 515821-22-4
• Molecular Formula: C₆₈H₁₀₄N₈O₁₈S₄
• Molecular Weight: 1449.88
• Mol file: 515821-22-4.mol

Synonyms:ethyl 2,3,4,6-tetra-O-[(6-(6-maleimidohexanamido)-3-thia-hexyl)]-α-D-galactopyranoside

Chemical Property of ethyl 2,3,4,6-tetra-O-[(6-(6-maleimidohexanamido)-3-thia-hexyl)]-α-D-galactopyranoside

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2,3,4,6-tetra-O-[(6-(6-maleimidohexanamido)-3-thia-hexyl)]-α-D-galactopyranoside

There total 2 articles about ethyl 2,3,4,6-tetra-O-[(6-(6-maleimidohexanamido)-3-thia-hexyl)]-α-D-galactopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

6-maleimidohexanoic acid N-hydroxylsuccinimide ester (55750-63-5) + ethyl 2,3,4,6-tetra-O-(6-amino-3-thia-hexyl)-α-D-galactopyranoside tetrahydrochloride → ethyl 2,3,4,6-tetra-O-[(6-(6-maleimidohexanamido)-3-thia-hexyl)]-α-D-galactopyranoside (515821-22-4)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; at 0 - 5 ℃; for 1h;

DOI:10.1016/S0968-0896(02)00339-5

Reference yield:

ethyl α-D-galactopyranoside (15486-24-5) → ethyl 2,3,4,6-tetra-O-[(6-(6-maleimidohexanamido)-3-thia-hexyl)]-α-D-galactopyranoside (515821-22-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / NaH / dimethylformamide / 4 h / 0 - 20 °C

2: 80 percent / AIBN / methanol / 24 h / Irradiation

3: 43 percent / aq. NaHCO₃ / tetrahydrofuran / 1 h / 0 - 5 °C

With 2,2'-azobis(isobutyronitrile); sodium hydride; sodium hydrogencarbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(02)00339-5

upstream raw materials:

6-maleimidohexanoic acid N-hydroxylsuccinimide ester

ethyl α-D-galactopyranoside