4-[allyl-(toluene-4-sulfonyl)-amino]-3-oxo-pentanoic acid dimethylamide

Base Information

Chemical Name:4-[allyl-(toluene-4-sulfonyl)-amino]-3-oxo-pentanoic acid dimethylamide
CAS No.:871123-31-8
Molecular Formula:C₁₇H₂₄N₂O₄S
Molecular Weight:352.455
Hs Code.:

Synonyms:4-[allyl-(toluene-4-sulfonyl)-amino]-3-oxo-pentanoic acid dimethylamide

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Chemical Property of 4-[allyl-(toluene-4-sulfonyl)-amino]-3-oxo-pentanoic acid dimethylamide

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Technology Process of 4-[allyl-(toluene-4-sulfonyl)-amino]-3-oxo-pentanoic acid dimethylamide

There total 3 articles about 4-[allyl-(toluene-4-sulfonyl)-amino]-3-oxo-pentanoic acid dimethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 127-19-5,116057-81-9
N,N-dimethyl acetamide

: 147048-44-0
N-Allyl-N-toluene-p-sulfonyl-(DL)-alanine methyl ester

: 871123-31-8
4-[allyl-(toluene-4-sulfonyl)-amino]-3-oxo-pentanoic acid dimethylamide

Guidance literature:: N,N-dimethyl acetamide; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃;

N-Allyl-N-toluene-p-sulfonyl-(DL)-alanine methyl ester; In tetrahydrofuran; hexane; at -78 - 20 ℃;
DOI:10.1021/ol052529c

Reference yield:

: 59724-69-5,51220-80-5
(±)-methyl 2-(4-methylphenylsulfonamido)propanoate

: 871123-31-8
4-[allyl-(toluene-4-sulfonyl)-amino]-3-oxo-pentanoic acid dimethylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 99 percent / K₂CO₃ / acetone / 14 h / Heating

2.1: LDA / tetrahydrofuran; hexane / -78 °C

2.2: 50 percent / tetrahydrofuran; hexane / -78 - 20 °C

With potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; hexane; acetone;
DOI:10.1021/ol052529c

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 871123-31-8
4-[allyl-(toluene-4-sulfonyl)-amino]-3-oxo-pentanoic acid dimethylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 100 percent / Et₃N / CH₂Cl₂ / 16 h / 20 °C

2.1: 99 percent / K₂CO₃ / acetone / 14 h / Heating

3.1: LDA / tetrahydrofuran; hexane / -78 °C

3.2: 50 percent / tetrahydrofuran; hexane / -78 - 20 °C

With potassium carbonate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; acetone;
DOI:10.1021/ol052529c