2-(2-methyl-4-oxohexanoyl)-1-(phenylsulfinylmethyl)-2,3-dihydro-1H-isoindole

Base Information

Chemical Name:2-(2-methyl-4-oxohexanoyl)-1-(phenylsulfinylmethyl)-2,3-dihydro-1H-isoindole
CAS No.:332143-56-3
Molecular Formula:C₂₂H₂₅NO₃S
Molecular Weight:383.511
Hs Code.:

Synonyms:2-(2-methyl-4-oxohexanoyl)-1-(phenylsulfinylmethyl)-2,3-dihydro-1H-isoindole

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Chemical Property of 2-(2-methyl-4-oxohexanoyl)-1-(phenylsulfinylmethyl)-2,3-dihydro-1H-isoindole

Chemical Property:

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Technology Process of 2-(2-methyl-4-oxohexanoyl)-1-(phenylsulfinylmethyl)-2,3-dihydro-1H-isoindole

There total 10 articles about 2-(2-methyl-4-oxohexanoyl)-1-(phenylsulfinylmethyl)-2,3-dihydro-1H-isoindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 332143-53-0
2-(2-methyl-4-oxohexanoyl)-1-(phenylthiomethyl)-2,3-dihydro-1H-isoindole

: 332143-56-3
2-(2-methyl-4-oxohexanoyl)-1-(phenylsulfinylmethyl)-2,3-dihydro-1H-isoindole

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃;
DOI:10.1016/S0040-4039(00)02138-9

Reference yield:

: 102539-95-7
2-methyl-4-oxo-hexanoic acid

: 332143-56-3
2-(2-methyl-4-oxohexanoyl)-1-(phenylsulfinylmethyl)-2,3-dihydro-1H-isoindole

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / (COCl)2; pyridine / benzene / 1 h / 20 °C

2: 35 mg / EDC; HOBt / CH₂Cl₂ / 1.5 h / 20 °C

3: 73 percent / MCPBA / CH₂Cl₂ / 0.5 h / 0 °C

With pyridine; oxalyl dichloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; benzene;
DOI:10.1021/jo030177m

Reference yield:

: 3959-05-5
2-bromobenzylamine

: 332143-56-3
2-(2-methyl-4-oxohexanoyl)-1-(phenylsulfinylmethyl)-2,3-dihydro-1H-isoindole

Guidance literature:: Multi-step reaction with 6 steps

1: 97 percent / MgSO₄ / diethyl ether / 15 h / 20 °C

2: 92 percent / Et₃N / toluene / 1 h / 20 °C

3: 85 percent / Bu₃SnH; AIBN / benzene / 4 h / Heating

4: K₂CO₃ / methanol; H₂O / 6 h / 20 °C

5: 35 mg / EDC; HOBt / CH₂Cl₂ / 1.5 h / 20 °C

6: 73 percent / MCPBA / CH₂Cl₂ / 0.5 h / 0 °C

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; magnesium sulfate; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; 3-chloro-benzenecarboperoxoic acid; In methanol; diethyl ether; dichloromethane; water; toluene; benzene;
DOI:10.1021/jo030177m