Bicyclo[2.2.1]heptane-2-methanol, 3-(methylamino)-, (endo,endo)- (9CI)

Base Information

• Chemical Name: Bicyclo[2.2.1]heptane-2-methanol, 3-(methylamino)-, (endo,endo)- (9CI)
• CAS No.: 95630-80-1
• Molecular Formula: C₉H₁₇NO
• Molecular Weight: 155.24
• Mol file: 95630-80-1.mol

Synonyms:Bicyclo[2.2.1]heptane-2-methanol, 3-(methylamino)-, (endo,endo)- (9CI)

Chemical Property of Bicyclo[2.2.1]heptane-2-methanol, 3-(methylamino)-, (endo,endo)- (9CI)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Bicyclo[2.2.1]heptane-2-methanol, 3-(methylamino)-, (endo,endo)- (9CI)

There total 5 articles about Bicyclo[2.2.1]heptane-2-methanol, 3-(methylamino)-, (endo,endo)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Ethyl 3-endo-Aminobicyclo<2.2.1>hept-5-ene-2-endo-carboxylate Hydrochloride (95630-74-3,104770-18-5,1242864-18-1) → 2-exo-Methylamino-3-exo-hydroxymethylbicyclo<2.2.1>heptane (95630-80-1,95630-81-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / H₂ / PtO₂ / ethanol / 6 h / 760 Torr / Ambient temperature

2: NaHCO₃ / H₂O / 12 h

3: LiAlH₄ / tetrahydrofuran / 1 h / Heating

With lithium aluminium tetrahydride; hydrogen; sodium hydrogencarbonate; platinum(IV) oxide; In tetrahydrofuran; ethanol; water;

Reference yield:

3-endo-Aminobicyclo<2.2.1>hept-5-ene-2-endo-carboxylic Acid (53623-52-2,88330-29-4,92511-32-5,202187-27-7,202187-24-4,202187-28-8,202187-29-9) → 2-exo-Methylamino-3-exo-hydroxymethylbicyclo<2.2.1>heptane (95630-80-1,95630-81-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 75 percent / SOCl₂ / 1.) -10 deg C - room temp., 3.5 h 2.) reflux, 1 h

2: 90 percent / H₂ / PtO₂ / ethanol / 6 h / 760 Torr / Ambient temperature

3: NaHCO₃ / H₂O / 12 h

4: LiAlH₄ / tetrahydrofuran / 1 h / Heating

With lithium aluminium tetrahydride; thionyl chloride; hydrogen; sodium hydrogencarbonate; platinum(IV) oxide; In tetrahydrofuran; ethanol; water;

Reference yield:

(1S,4R)-3-Ethoxycarbonylamino-bicyclo[2.2.1]heptane-2-carboxylic acid ethyl ester (95630-63-0,95630-64-1) → 2-exo-Methylamino-3-exo-hydroxymethylbicyclo<2.2.1>heptane (95630-80-1,95630-81-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 1h; Yield given; Heating;

upstream raw materials:

(1S,4R)-3-Ethoxycarbonylamino-bicyclo[2.2.1]heptane-2-carboxylic acid ethyl ester

Ethyl 3-endo-Aminobicyclo<2.2.1>hept-5-ene-2-endo-carboxylate Hydrochloride

3-exo-Aminobicyclo<2.2.1>heptane-2-exo-carboxylic Acid

3-endo-Aminobicyclo<2.2.1>hept-5-ene-2-endo-carboxylic Acid

Downstream raw materials:

[(1S,2R,7S,8R)-3-Methyl-5-thia-3-aza-tricyclo[6.2.1.0^2,7]undec-(4Z)-ylidene]-phenyl-amine

[(1S,2R,7S,8R)-3-Methyl-5-oxa-3-aza-tricyclo[6.2.1.0^2,7]undec-(4Z)-ylidene]-phenyl-amine

1-((1R,2S,3R,4S)-3-Hydroxymethyl-bicyclo[2.2.1]hept-2-yl)-1-methyl-3-phenyl-thiourea

[(1R,2R,7S,8S)-3-Methyl-5-thia-3-aza-tricyclo[6.2.1.0^2,7]undec-(4Z)-ylidene]-phenyl-amine