N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-4-(1-(2-(2-(2-fluoroethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)-benzamide

Base Information

Chemical Name:N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-4-(1-(2-(2-(2-fluoroethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)-benzamide
CAS No.:1609428-66-1
Molecular Formula:C₃₀H₄₀FN₅O₅
Molecular Weight:569.677
Hs Code.:

Synonyms:N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-4-(1-(2-(2-(2-fluoroethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)-benzamide

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Chemical Property of N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-4-(1-(2-(2-(2-fluoroethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)-benzamide

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Technology Process of N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-4-(1-(2-(2-(2-fluoroethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)-benzamide

There total 6 articles about N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-4-(1-(2-(2-(2-fluoroethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19249-03-7
triethylene glycol di-(p-toluenesulfonate)

: 1609428-66-1
N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-4-(1-(2-(2-(2-fluoroethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / Reflux; Inert atmosphere

2: sodium azide / N,N-dimethyl-formamide

3: triethylamine; copper(l) iodide / N,N-dimethyl-formamide / Inert atmosphere

With copper(l) iodide; sodium azide; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm5001453

Reference yield:

: 2328-12-3
6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline monohydrochloride

: 1609428-66-1
N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-4-(1-(2-(2-(2-fluoroethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / Inert atmosphere

2: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C / Reflux; Inert atmosphere

3: dicyclohexyl-carbodiimide; benzotriazol-1-ol / dichloromethane / 0 °C / Inert atmosphere

4: triethylamine; copper(l) iodide / N,N-dimethyl-formamide / Inert atmosphere

With copper(l) iodide; lithium aluminium tetrahydride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm5001453

Reference yield:

: 669067-79-2
4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butanenitrile

: 1609428-66-1
N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-4-(1-(2-(2-(2-fluoroethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C / Reflux; Inert atmosphere

2: dicyclohexyl-carbodiimide; benzotriazol-1-ol / dichloromethane / 0 °C / Inert atmosphere

3: triethylamine; copper(l) iodide / N,N-dimethyl-formamide / Inert atmosphere

With copper(l) iodide; lithium aluminium tetrahydride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm5001453