(S)-8-benzoylamino-3-[3-(4,4'-dimethoxytrityloxy)-2-hydroxypropyl]imidazo[4',5':5,6]pyrido[2,3-d]pyrimidine

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Chemical Name:(S)-8-benzoylamino-3-[3-(4,4'-dimethoxytrityloxy)-2-hydroxypropyl]imidazo[4',5':5,6]pyrido[2,3-d]pyrimidine
CAS No.:1187577-44-1
Molecular Formula:C₃₉H₃₄N₆O₅
Molecular Weight:666.736
Hs Code.:

Synonyms:(S)-8-benzoylamino-3-[3-(4,4'-dimethoxytrityloxy)-2-hydroxypropyl]imidazo[4',5':5,6]pyrido[2,3-d]pyrimidine

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Chemical Property of (S)-8-benzoylamino-3-[3-(4,4'-dimethoxytrityloxy)-2-hydroxypropyl]imidazo[4',5':5,6]pyrido[2,3-d]pyrimidine

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Technology Process of (S)-8-benzoylamino-3-[3-(4,4'-dimethoxytrityloxy)-2-hydroxypropyl]imidazo[4',5':5,6]pyrido[2,3-d]pyrimidine

There total 7 articles about (S)-8-benzoylamino-3-[3-(4,4'-dimethoxytrityloxy)-2-hydroxypropyl]imidazo[4',5':5,6]pyrido[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1187577-43-0
(S)-8-benzoylamino-3-[2,3-dihydroxypropyl]imidazo[4',5':5,6]pyrido[2,3-d]pyrimidine

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 1187577-44-1
(S)-8-benzoylamino-3-[3-(4,4'-dimethoxytrityloxy)-2-hydroxypropyl]imidazo[4',5':5,6]pyrido[2,3-d]pyrimidine

Guidance literature:: With pyridine; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2011.11.045

Reference yield:

: 1187577-40-7
(S)-8-amino-3-[2,3-dihydroxypropyl]imidazo[4',5':5,6]pyrido[2,3-d]pyrimidine

: 1187577-44-1
(S)-8-benzoylamino-3-[3-(4,4'-dimethoxytrityloxy)-2-hydroxypropyl]imidazo[4',5':5,6]pyrido[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 18 h / 20 °C

2: pyridine / 10 h / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

4: pyridine / 2 h / 20 °C

With pyridine; 1H-imidazole; tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.11.045

Reference yield:

: 1187577-38-3
(S)-5-amino-6-cyano-3-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]imidazo[4,5-b]pyridine

: 1187577-44-1
(S)-8-benzoylamino-3-[3-(4,4'-dimethoxytrityloxy)-2-hydroxypropyl]imidazo[4',5':5,6]pyrido[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: 54 h / 100 °C

1.2: 18 h / 110 °C

2.1: acetic acid / 9 h / 60 °C

3.1: 1H-imidazole / N,N-dimethyl-formamide / 18 h / 20 °C

4.1: pyridine / 10 h / 20 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

6.1: pyridine / 2 h / 20 °C

With pyridine; 1H-imidazole; tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.11.045