O-[3-(3-Chlorophenyl)-2-propyn-1-yl]hydroxylamine

Base Information

Chemical Name:O-[3-(3-Chlorophenyl)-2-propyn-1-yl]hydroxylamine
CAS No.:754159-80-3
Molecular Formula:C₉H₈ClNO
Molecular Weight:181.622
Hs Code.:
DSSTox Substance ID:DTXSID801231250

Synonyms:DTXSID801231250;O-[3-(3-Chlorophenyl)-2-propyn-1-yl]hydroxylamine;754159-80-3

Suppliers and Price of O-[3-(3-Chlorophenyl)-2-propyn-1-yl]hydroxylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of O-[3-(3-Chlorophenyl)-2-propyn-1-yl]hydroxylamine

Chemical Property:

XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:181.0294416
Heavy Atom Count:12
Complexity:193

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC(=C1)Cl)C#CCON

Technology Process of O-[3-(3-Chlorophenyl)-2-propyn-1-yl]hydroxylamine

There total 3 articles about O-[3-(3-Chlorophenyl)-2-propyn-1-yl]hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[3-(3-Chloro-phenyl)-prop-2-ynyloxy]-isoindole-1,3-dione

: 754159-80-3
O-[3-(3-Chloro-phenyl)-prop-2-ynyl]-hydroxylamine

Guidance literature:: With methylhydrazine; In dichloromethane; for 3h; Ambient temperature;
DOI:10.1021/jm960683m

Reference yield:

: 625-99-0
3-iodochlorobenzene

: 754159-80-3
O-[3-(3-Chloro-phenyl)-prop-2-ynyl]-hydroxylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / CuI, Et₃N, PdP(Ph₃)4 / tetrahydrofuran / 16 h / Ambient temperature

2: 52 percent / diethyl azodicarboxylate, Ph₃P / tetrahydrofuran / 24 h / Ambient temperature

3: H₂NNHCH₃ / CH₂Cl₂ / 3 h / Ambient temperature

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; triphenylphosphine; methylhydrazine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm960683m

Reference yield:

: 80151-33-3
3-(3-chlorophenyl)prop-2-yn-1-ol,

: 754159-80-3
O-[3-(3-Chloro-phenyl)-prop-2-ynyl]-hydroxylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 52 percent / diethyl azodicarboxylate, Ph₃P / tetrahydrofuran / 24 h / Ambient temperature

2: H₂NNHCH₃ / CH₂Cl₂ / 3 h / Ambient temperature

With triphenylphosphine; methylhydrazine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm960683m