5-bromo-1-(2,3-dihydroxypropyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylic acid methyl ester

Base Information

Chemical Name:5-bromo-1-(2,3-dihydroxypropyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylic acid methyl ester
CAS No.:1206103-62-9
Molecular Formula:C₁₇H₁₈BrNO₆
Molecular Weight:412.237
Hs Code.:

Synonyms:5-bromo-1-(2,3-dihydroxypropyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylic acid methyl ester

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Chemical Property of 5-bromo-1-(2,3-dihydroxypropyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylic acid methyl ester

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Technology Process of 5-bromo-1-(2,3-dihydroxypropyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylic acid methyl ester

There total 10 articles about 5-bromo-1-(2,3-dihydroxypropyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.6%

: 1206102-07-9
1-(2,3-dihydroxypropyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylic acid methyl ester

: 1206103-62-9
5-bromo-1-(2,3-dihydroxypropyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylic acid methyl ester

Guidance literature:: With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 18 - 20 ℃; for 16.3333h;

Reference yield:

: 118-71-8
Maltol

: 1206103-62-9
5-bromo-1-(2,3-dihydroxypropyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / acetonitrile / 5 h / 13 - 80 °C / Large scale

2: bromobenzene; selenium(IV) oxide / 13 h / 140 °C / Dean-Stark

3: sodium chlorite; aminosulfonic acid / water; acetone / 0.67 h / 20 °C / Cooling with ice

4: ethanol / 8.5 h / 65 - 80 °C

5: sodium hydrogencarbonate / 1-methyl-pyrrolidin-2-one; water / 28 - 35 °C / Large scale

6: N-Bromosuccinimide / N,N-dimethyl-formamide / 16 h / 18 - 20 °C / Large scale

With selenium(IV) oxide; sodium chlorite; N-Bromosuccinimide; bromobenzene; aminosulfonic acid; sodium hydrogencarbonate; potassium carbonate; In 1-methyl-pyrrolidin-2-one; ethanol; water; N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

: 61049-69-2
3-O-benzylmaltol

: 1206103-62-9
5-bromo-1-(2,3-dihydroxypropyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: bromobenzene; selenium(IV) oxide / 13 h / 140 °C / Dean-Stark

2: sodium chlorite; aminosulfonic acid / water; acetone / 0.67 h / 20 °C / Cooling with ice

3: ethanol / 8.5 h / 65 - 80 °C

4: sodium hydrogencarbonate / 1-methyl-pyrrolidin-2-one; water / 28 - 35 °C / Large scale

5: N-Bromosuccinimide / N,N-dimethyl-formamide / 16 h / 18 - 20 °C / Large scale

With selenium(IV) oxide; sodium chlorite; N-Bromosuccinimide; bromobenzene; aminosulfonic acid; sodium hydrogencarbonate; In 1-methyl-pyrrolidin-2-one; ethanol; water; N,N-dimethyl-formamide; acetone;