4-(3-Chloro-propyl)-1-phenyl-isoquinoline-3-carboxylic acid ethyl ester

Base Information

Chemical Name:4-(3-Chloro-propyl)-1-phenyl-isoquinoline-3-carboxylic acid ethyl ester
CAS No.:1027370-34-8
Molecular Formula:C₂₁H₂₀ClNO₂
Molecular Weight:353.848
Hs Code.:

Synonyms:4-(3-Chloro-propyl)-1-phenyl-isoquinoline-3-carboxylic acid ethyl ester

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Chemical Property of 4-(3-Chloro-propyl)-1-phenyl-isoquinoline-3-carboxylic acid ethyl ester

Chemical Property:

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Technology Process of 4-(3-Chloro-propyl)-1-phenyl-isoquinoline-3-carboxylic acid ethyl ester

There total 4 articles about 4-(3-Chloro-propyl)-1-phenyl-isoquinoline-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 94905-48-3
4-hydroxy-1-phenyl-isoquinoline-3-carboxylic acid ethyl ester

: 1027370-34-8
4-(3-Chloro-propyl)-1-phenyl-isoquinoline-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / pyridine / Ambient temperature

2: 1.) Et₃N, CuI, 2.) Pd(PPh₃)Cl₂ / 1.) DMF, 10 min, 2.) DMF, 60-65 deg C, 45 min

3: 78 percent / H₂ / 10percent Pd/C / ethanol / 4 h / 1292.9 Torr / Ambient temperature

4: SOCl₂ / CH₂Cl₂ / 2 h / Ambient temperature

With pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; thionyl chloride; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jm960516m

Reference yield:

: 194224-17-4
4-(3-Hydroxy-prop-1-ynyl)-1-phenyl-isoquinoline-3-carboxylic acid ethyl ester

: 1027370-34-8
4-(3-Chloro-propyl)-1-phenyl-isoquinoline-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / H₂ / 10percent Pd/C / ethanol / 4 h / 1292.9 Torr / Ambient temperature

2: SOCl₂ / CH₂Cl₂ / 2 h / Ambient temperature

With thionyl chloride; hydrogen; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jm960516m

Reference yield:

: 194224-13-0
1-Phenyl-4-trifluoromethanesulfonyloxy-isoquinoline-3-carboxylic acid ethyl ester

: 1027370-34-8
4-(3-Chloro-propyl)-1-phenyl-isoquinoline-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Et₃N, CuI, 2.) Pd(PPh₃)Cl₂ / 1.) DMF, 10 min, 2.) DMF, 60-65 deg C, 45 min

2: 78 percent / H₂ / 10percent Pd/C / ethanol / 4 h / 1292.9 Torr / Ambient temperature

3: SOCl₂ / CH₂Cl₂ / 2 h / Ambient temperature

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; thionyl chloride; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jm960516m