butyl(chloromethyl)(3-nitrophenyl)phosphine oxide

Base Information

• Chemical Name: butyl(chloromethyl)(3-nitrophenyl)phosphine oxide
• CAS No.: 129379-72-2
• Molecular Formula: C₁₁H₁₅ClNO₃P
• Molecular Weight: 275.672
• Mol file: 129379-72-2.mol

Synonyms:1-(Butyl-chloromethyl-phosphinoyl)-3-nitro-benzene

Chemical Property of butyl(chloromethyl)(3-nitrophenyl)phosphine oxide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of butyl(chloromethyl)(3-nitrophenyl)phosphine oxide

There total 3 articles about butyl(chloromethyl)(3-nitrophenyl)phosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

butyl(chloromethyl)phenylphosphine oxide (129379-68-6) → 1-(Butyl-chloromethyl-phosphinoyl)-3-nitro-benzene (129379-72-2)

Guidance literature:

With sulfuric acid; nitric acid; at 0 - 5 ℃; for 1h;

Reference yield:

butylphenylphosphinous acid (117107-53-6) → 1-(Butyl-chloromethyl-phosphinoyl)-3-nitro-benzene (129379-72-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / 0.1 N sodium ethoxide / ethanol / 0.5 h / Heating

2: 78 percent / PCl₅ / benzene / 0.5 h / Heating

3: 87 percent / fuming HNO₃, conc. H₂SO₄ / 1 h / 0 - 5 °C

With phosphorus pentachloride; sulfuric acid; nitric acid; sodium ethanolate; In ethanol; benzene;

Reference yield:

n-butyl(1-hydroxymethyl)phenylphosphine oxide (129379-79-9) → 1-(Butyl-chloromethyl-phosphinoyl)-3-nitro-benzene (129379-72-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / PCl₅ / benzene / 0.5 h / Heating

2: 87 percent / fuming HNO₃, conc. H₂SO₄ / 1 h / 0 - 5 °C

With phosphorus pentachloride; sulfuric acid; nitric acid; In benzene;

upstream raw materials:

butyl(chloromethyl)phenylphosphine oxide

butylphenylphosphinous acid

n-butyl(1-hydroxymethyl)phenylphosphine oxide

Downstream raw materials:

C₁₇H₁₉N₂O₆P