methyl 4-(5-oxo-4-(4-(piperazin-1-ylmethyl)phenylamino)-5,6-dihydropyrimido[4,5-d]pyridazin-2-yl)benzoate hydrochloride

Base Information

Chemical Name:methyl 4-(5-oxo-4-(4-(piperazin-1-ylmethyl)phenylamino)-5,6-dihydropyrimido[4,5-d]pyridazin-2-yl)benzoate hydrochloride
CAS No.:1425379-72-1
Molecular Formula:C₂₅H₂₅N₇O₃*ClH
Molecular Weight:507.98
Hs Code.:

Synonyms:methyl 4-(5-oxo-4-(4-(piperazin-1-ylmethyl)phenylamino)-5,6-dihydropyrimido[4,5-d]pyridazin-2-yl)benzoate hydrochloride

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Chemical Property of methyl 4-(5-oxo-4-(4-(piperazin-1-ylmethyl)phenylamino)-5,6-dihydropyrimido[4,5-d]pyridazin-2-yl)benzoate hydrochloride

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Technology Process of methyl 4-(5-oxo-4-(4-(piperazin-1-ylmethyl)phenylamino)-5,6-dihydropyrimido[4,5-d]pyridazin-2-yl)benzoate hydrochloride

There total 7 articles about methyl 4-(5-oxo-4-(4-(piperazin-1-ylmethyl)phenylamino)-5,6-dihydropyrimido[4,5-d]pyridazin-2-yl)benzoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1425383-98-7
tert-butyl 4-(4-(2-(4-(methoxycarbonyl)phenyl)-5-oxo-5,6-dihydropyrimido[4,5-d]pyridazin-4-ylamino)benzyl)piperazine-1-carboxylate

: 1425379-72-1
methyl 4-(5-oxo-4-(4-(piperazin-1-ylmethyl)phenylamino)-5,6-dihydropyrimido[4,5-d]pyridazin-2-yl)benzoate hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1.5h;

Reference yield:

: 81397-18-4
(Z)-ethyl 3-amino-2-(ethoxycarbonylcarbamothioyl)but-2-enoate

: 1425379-72-1
methyl 4-(5-oxo-4-(4-(piperazin-1-ylmethyl)phenylamino)-5,6-dihydropyrimido[4,5-d]pyridazin-2-yl)benzoate hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / water / 2 h / 70 °C

2: trichlorophosphate; tributyl-amine / 5 h / 0 - 90 °C

3: 1-methyl-pyrrolidin-2-one / 2 h / 0 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 3 h / 100 °C

5: selenium(IV) oxide / 1,4-dioxane; water / 3.5 h / 100 °C

6: hydrazine hydrate / ethanol / 2.5 h / Reflux

7: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C

With hydrogenchloride; selenium(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrazine hydrate; tributyl-amine; potassium carbonate; triethylamine; trichlorophosphate; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; water;

Reference yield:

: 13996-05-9
ethyl 2-hydroxy-4-mercapto-6-methylpyrimidine-5-carboxylate

: 1425379-72-1
methyl 4-(5-oxo-4-(4-(piperazin-1-ylmethyl)phenylamino)-5,6-dihydropyrimido[4,5-d]pyridazin-2-yl)benzoate hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: trichlorophosphate; tributyl-amine / 5 h / 0 - 90 °C

2: 1-methyl-pyrrolidin-2-one / 2 h / 0 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 3 h / 100 °C

4: selenium(IV) oxide / 1,4-dioxane; water / 3.5 h / 100 °C

5: hydrazine hydrate / ethanol / 2.5 h / Reflux

6: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C

With hydrogenchloride; selenium(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrazine hydrate; tributyl-amine; potassium carbonate; trichlorophosphate; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; water;