(E)-methyl 3-(5-benzyl-4-(2-(3-methoxy-3-oxopropyl)-2H-tetrazol-5-yl)thiophen-2-yl)acrylate

Base Information

Chemical Name:(E)-methyl 3-(5-benzyl-4-(2-(3-methoxy-3-oxopropyl)-2H-tetrazol-5-yl)thiophen-2-yl)acrylate
CAS No.:1073314-14-3
Molecular Formula:C₂₀H₂₀N₄O₄S
Molecular Weight:412.469
Hs Code.:

Synonyms:(E)-methyl 3-(5-benzyl-4-(2-(3-methoxy-3-oxopropyl)-2H-tetrazol-5-yl)thiophen-2-yl)acrylate

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Chemical Property of (E)-methyl 3-(5-benzyl-4-(2-(3-methoxy-3-oxopropyl)-2H-tetrazol-5-yl)thiophen-2-yl)acrylate

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Technology Process of (E)-methyl 3-(5-benzyl-4-(2-(3-methoxy-3-oxopropyl)-2H-tetrazol-5-yl)thiophen-2-yl)acrylate

There total 5 articles about (E)-methyl 3-(5-benzyl-4-(2-(3-methoxy-3-oxopropyl)-2H-tetrazol-5-yl)thiophen-2-yl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-(2-benzyl-5-iodothiophen-3-yl)-2-trityl-2H-tetrazole

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 1073314-14-3
(E)-methyl 3-(5-benzyl-4-(2-(3-methoxy-3-oxopropyl)-2H-tetrazol-5-yl)thiophen-2-yl)acrylate

Guidance literature:: With 1,3-bis-(diphenylphosphino)propane; triethylamine; palladium diacetate; In N,N-dimethyl-formamide; at 100 ℃; for 24h;

Reference yield:

: 59918-86-4
5-(thiophen-3-yl)-1H-tetrazole

: 1073314-14-3
(E)-methyl 3-(5-benzyl-4-(2-(3-methoxy-3-oxopropyl)-2H-tetrazol-5-yl)thiophen-2-yl)acrylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 0.17 h / 20 °C

1.2: 1 h

2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Cooling with acetone-dry ice

2.2: 0.5 h / -78 - 20 °C

3.1: N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium / tetrahydrofuran / 1 h / -78 °C / Cooling with acetone-dry ice

3.2: 1 h / -78 °C

4.1: 1,3-bis-(diphenylphosphino)propane; triethylamine / palladium diacetate / N,N-dimethyl-formamide / 24 h / 100 °C

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; 1,3-bis-(diphenylphosphino)propane; tert.-butyl lithium; triethylamine; palladium diacetate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1641-09-4
3-thiophenecarbonitrile

: 1073314-14-3
(E)-methyl 3-(5-benzyl-4-(2-(3-methoxy-3-oxopropyl)-2H-tetrazol-5-yl)thiophen-2-yl)acrylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium azide; zinc dibromide / N,N-dimethyl-formamide / 5 h / Heating / reflux

2.1: triethylamine / tetrahydrofuran / 0.17 h / 20 °C

2.2: 1 h

3.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Cooling with acetone-dry ice

3.2: 0.5 h / -78 - 20 °C

4.1: N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium / tetrahydrofuran / 1 h / -78 °C / Cooling with acetone-dry ice

4.2: 1 h / -78 °C

5.1: 1,3-bis-(diphenylphosphino)propane; triethylamine / palladium diacetate / N,N-dimethyl-formamide / 24 h / 100 °C

With n-butyllithium; sodium azide; N,N,N,N,-tetramethylethylenediamine; 1,3-bis-(diphenylphosphino)propane; tert.-butyl lithium; triethylamine; zinc dibromide; palladium diacetate; In tetrahydrofuran; N,N-dimethyl-formamide;