[ribose-13C5]-1-(2-O-acetyl-3,5-di-O-benzoyl-β-D-ribofuranosyl)-5-methyluracil

Base Information

Chemical Name:[ribose-13C5]-1-(2-O-acetyl-3,5-di-O-benzoyl-β-D-ribofuranosyl)-5-methyluracil
CAS No.:503173-76-0
Molecular Formula:C₂₆H₂₄N₂O₉
Molecular Weight:513.43
Hs Code.:

Synonyms:[ribose-13C5]-1-(2-O-acetyl-3,5-di-O-benzoyl-β-D-ribofuranosyl)-5-methyluracil

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Chemical Property of [ribose-13C5]-1-(2-O-acetyl-3,5-di-O-benzoyl-β-D-ribofuranosyl)-5-methyluracil

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Technology Process of [ribose-13C5]-1-(2-O-acetyl-3,5-di-O-benzoyl-β-D-ribofuranosyl)-5-methyluracil

There total 8 articles about [ribose-13C5]-1-(2-O-acetyl-3,5-di-O-benzoyl-β-D-ribofuranosyl)-5-methyluracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 65-71-4,28806-14-6,691841-57-3
thymin

: 503173-75-9
¹³C₅-1′, 2 ′-di-O-acetyl-3 ′ ,5 ′-di-O-benzoyl-β-D-ribofuranose

: 503173-76-0
[ribose-13C5]-1-(2-O-acetyl-3,5-di-O-benzoyl-β-D-ribofuranosyl)-5-methyluracil

Guidance literature:: thymin; With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane; Heating;

¹³C₅-1′, 2 ′-di-O-acetyl-3 ′ ,5 ′-di-O-benzoyl-β-D-ribofuranose; With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; for 3.5h; Heating;
DOI:10.1016/S0040-4020(02)01246-2

Reference yield:

: 159496-09-0
[13C5]-1,2-di-O-acetyl-3,5-di-O-benzoyl-α,β-D-ribofuranose

: 7288-28-0
2,4-bis(trimethylsiloxy)-5-methylpyrimidine

: 503173-76-0
[ribose-13C5]-1-(2-O-acetyl-3,5-di-O-benzoyl-β-D-ribofuranosyl)-5-methyluracil

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In 1,2-dichloro-ethane; at 0 ℃; Yield given;
DOI:10.1016/S0040-4039(97)00080-4

Reference yield:

: 126590-65-6
<1,2,3,4,5,6-13C6>-1,2:5,6-di-O-isopropylidene-α-D-glucofuranose

: 503173-76-0
[ribose-13C5]-1-(2-O-acetyl-3,5-di-O-benzoyl-β-D-ribofuranosyl)-5-methyluracil

Guidance literature:: Multi-step reaction with 5 steps

1.1: 94 percent / pyridinium dichromate; acetic anhydride / CH₂Cl₂ / 1.5 h / Heating

2.1: H₅IO₆ / ethyl acetate / 2 h / 20 °C

2.2: 80 percent / NaBH₄ / ethanol / 0.5 h

3.1: 95 percent / pyridine / 3 h / 20 °C

4.1: 87 percent / H₂SO₄; AcOH / 20 °C

5.1: HMDS; (NH₄)2SO₄ / Heating

5.2: 89 percent / TMSOTf / CH₂Cl₂ / 3.5 h / Heating

With pyridine; ammonium sulfate; dipyridinium dichromate; sulfuric acid; acetic anhydride; acetic acid; periodic acid; 1,1,1,3,3,3-hexamethyl-disilazane; In dichloromethane; ethyl acetate;
DOI:10.1016/S0040-4020(02)01246-2