4'-((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-2-(((((S)-tetrahydrofuran-3-yl)oxy)carbonyl)amino)butyl)-[1,1'-biphenyl]-4-carboxylic acid

Base Information

Chemical Name:4'-((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-2-(((((S)-tetrahydrofuran-3-yl)oxy)carbonyl)amino)butyl)-[1,1'-biphenyl]-4-carboxylic acid
CAS No.:1335386-94-1
Molecular Formula:C₃₃H₄₀N₂O₉S
Molecular Weight:640.755
Hs Code.:

4'-((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-2-(((((S)-tetrahydrofuran-3-yl)oxy)carbonyl)amino)butyl)-[1,1'-biphenyl]-4-carboxylic acid

Synonyms:4'-((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-2-(((((S)-tetrahydrofuran-3-yl)oxy)carbonyl)amino)butyl)-[1,1'-biphenyl]-4-carboxylic acid

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Chemical Property of 4'-((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-2-(((((S)-tetrahydrofuran-3-yl)oxy)carbonyl)amino)butyl)-[1,1'-biphenyl]-4-carboxylic acid

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Technology Process of 4'-((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-2-(((((S)-tetrahydrofuran-3-yl)oxy)carbonyl)amino)butyl)-[1,1'-biphenyl]-4-carboxylic acid

There total 10 articles about 4'-((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-2-(((((S)-tetrahydrofuran-3-yl)oxy)carbonyl)amino)butyl)-[1,1'-biphenyl]-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1335387-28-4
C₂₆H₃₅IN₂O₇S

: 14047-29-1
4-carboxyphenylboronic acid

: 1335386-94-1
4'-((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-2-(((((S)-tetrahydrofuran-3-yl)oxy)carbonyl)amino)butyl)-[1,1'-biphenyl]-4-carboxylic acid

Guidance literature:: With palladium 10% on activated carbon; potassium carbonate; In ethanol; water; toluene; at 80 ℃; for 8h;
DOI:10.1016/j.bmcl.2012.01.037

Reference yield:

: C₂₂H₂₉IN₂O₆S

: 1335386-94-1
4'-((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-2-(((((S)-tetrahydrofuran-3-yl)oxy)carbonyl)amino)butyl)-[1,1'-biphenyl]-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: bis(trichloromethyl) carbonate; triethylamine / dichloromethane

2: palladium 10% on activated carbon; potassium carbonate / ethanol; water; toluene / 8 h / 80 °C

With bis(trichloromethyl) carbonate; palladium 10% on activated carbon; potassium carbonate; triethylamine; In ethanol; dichloromethane; water; toluene; 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2012.01.037

Reference yield:

: 1335387-17-1
C₁₅H₁₉ClINO₃

: 1335386-94-1
4'-((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-2-(((((S)-tetrahydrofuran-3-yl)oxy)carbonyl)amino)butyl)-[1,1'-biphenyl]-4-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: sodium tetrahydroborate / ethanol / -78 °C

2: potassium carbonate / methanol

3: ethanol

4: sodium hydrogencarbonate / dichloromethane; water

5: hydrogenchloride / 1,4-dioxane

6: bis(trichloromethyl) carbonate; triethylamine / dichloromethane

7: palladium 10% on activated carbon; potassium carbonate / ethanol; water; toluene / 8 h / 80 °C

With hydrogenchloride; sodium tetrahydroborate; bis(trichloromethyl) carbonate; palladium 10% on activated carbon; sodium hydrogencarbonate; potassium carbonate; triethylamine; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; toluene; 7: Suzuki coupling;
DOI:10.1016/j.bmcl.2012.01.037