1-(2,5-difluoro-phenyl)-2-(3-isopropyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-ethanone

Base Information

Chemical Name:1-(2,5-difluoro-phenyl)-2-(3-isopropyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-ethanone
CAS No.:908837-12-7
Molecular Formula:C₁₇H₁₅F₂N₃O
Molecular Weight:315.322
Hs Code.:

1-(2,5-difluoro-phenyl)-2-(3-isopropyl-[1,2,4]triazolo[4,3-<i>a</i>]pyridin-6-yl)-ethanone

Synonyms:1-(2,5-difluoro-phenyl)-2-(3-isopropyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-ethanone

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Chemical Property of 1-(2,5-difluoro-phenyl)-2-(3-isopropyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-ethanone

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Technology Process of 1-(2,5-difluoro-phenyl)-2-(3-isopropyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-ethanone

There total 1 articles about 1-(2,5-difluoro-phenyl)-2-(3-isopropyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 459448-04-5
3-isopropyl-[1,2,4]triazolo[4,3-a]-6-pyridinecarboxaldehyde

: [(2,5-difluoro-phenyl)-phenylamino-methyl]-phosphonic acid diphenyl ester

: 908837-12-7
1-(2,5-difluoro-phenyl)-2-(3-isopropyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-ethanone

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; isopropyl alcohol; at 23 ℃; for 0.75h;
DOI:10.1016/j.bmcl.2006.05.056

Reference yield: 100.0%

: 908837-12-7
1-(2,5-difluoro-phenyl)-2-(3-isopropyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-ethanone

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 908837-16-1
3-(2,5-difluoro-phenyl)-2-(3-isopropyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-3-oxo-propionaldehyde

Guidance literature:: at 90 ℃; for 1h;
DOI:10.1016/j.bmcl.2006.05.056

Reference yield:

: 908837-12-7
1-(2,5-difluoro-phenyl)-2-(3-isopropyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-ethanone

: 6-[3-(2,5-difluoro-phenyl)-1H-pyrazol-4-yl]-3-isopropyl-[1,2,4]triazolo[4,3-a]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / 1 h / 90 °C

2: 56 percent / hydrazine hydrate / ethanol; H₂O / 0.5 h / 70 °C

With hydrazine hydrate; In ethanol; water;
DOI:10.1016/j.bmcl.2006.05.056