(S)-2-Acetylamino-3-{3-[(S)-2-(4-benzyloxycarbonylamino-butyrylamino)-2-methoxycarbonyl-ethyl]-phenyl}-propionic acid benzyl ester

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Chemical Name:(S)-2-Acetylamino-3-{3-[(S)-2-(4-benzyloxycarbonylamino-butyrylamino)-2-methoxycarbonyl-ethyl]-phenyl}-propionic acid benzyl ester
CAS No.:218927-37-8
Molecular Formula:C₃₄H₃₉N₃O₈
Molecular Weight:617.699
Hs Code.:

Synonyms:(S)-2-Acetylamino-3-{3-[(S)-2-(4-benzyloxycarbonylamino-butyrylamino)-2-methoxycarbonyl-ethyl]-phenyl}-propionic acid benzyl ester

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Chemical Property of (S)-2-Acetylamino-3-{3-[(S)-2-(4-benzyloxycarbonylamino-butyrylamino)-2-methoxycarbonyl-ethyl]-phenyl}-propionic acid benzyl ester

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Technology Process of (S)-2-Acetylamino-3-{3-[(S)-2-(4-benzyloxycarbonylamino-butyrylamino)-2-methoxycarbonyl-ethyl]-phenyl}-propionic acid benzyl ester

There total 5 articles about (S)-2-Acetylamino-3-{3-[(S)-2-(4-benzyloxycarbonylamino-butyrylamino)-2-methoxycarbonyl-ethyl]-phenyl}-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 5105-78-2
4-(benzyloxycarbonylamino)butyric acid

: (S)-2-Acetylamino-3-[3-((S)-2-amino-2-methoxycarbonyl-ethyl)-phenyl]-propionic acid benzyl ester

: 218927-37-8
(S)-2-Acetylamino-3-{3-[(S)-2-(4-benzyloxycarbonylamino-butyrylamino)-2-methoxycarbonyl-ethyl]-phenyl}-propionic acid benzyl ester

Guidance literature:: With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1.) 0 deg C, 1 h, 2.) r.t., 16 h;
DOI:10.1039/a805350b

Reference yield:

: 591-18-4
1-Bromo-3-iodobenzene

: 218927-37-8
(S)-2-Acetylamino-3-{3-[(S)-2-(4-benzyloxycarbonylamino-butyrylamino)-2-methoxycarbonyl-ethyl]-phenyl}-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 63 percent / NaHCO₃, Bu₄NCl, hydroquinone / Pd(OAc)2 / dimethylformamide / 18 h / 60 °C

2: 57 percent / NaHCO₃, Bu₄NCl, hydroquinone / Pd(OAc)2 / dimethylformamide / 85 °C

3: 98 percent / H₂ / >⁽¹⁺⁾*OTf^(1-) / methanol / 6 h / 2068.6 Torr / Ambient temperature

4: TFA / 0.25 h / Ambient temperature

5: 61 percent / Et₃N, HOBt*H₂O, DCC / tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) r.t., 16 h

With tetrabutyl-ammonium chloride; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; triethylamine; hydroquinone; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium diacetate; benzene; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1039/a805350b

Reference yield:

: 218927-23-2
(Z)-3-(3-Bromo-phenyl)-2-tert-butoxycarbonylamino-acrylic acid methyl ester

: 218927-37-8
(S)-2-Acetylamino-3-{3-[(S)-2-(4-benzyloxycarbonylamino-butyrylamino)-2-methoxycarbonyl-ethyl]-phenyl}-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 57 percent / NaHCO₃, Bu₄NCl, hydroquinone / Pd(OAc)2 / dimethylformamide / 85 °C

2: 98 percent / H₂ / >⁽¹⁺⁾*OTf^(1-) / methanol / 6 h / 2068.6 Torr / Ambient temperature

3: TFA / 0.25 h / Ambient temperature

4: 61 percent / Et₃N, HOBt*H₂O, DCC / tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) r.t., 16 h

With tetrabutyl-ammonium chloride; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; triethylamine; hydroquinone; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium diacetate; benzene; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1039/a805350b