[6-(3-methoxyphenyl)-8-naphthalen-1-yl-quinolin-2-yl]phosphonic acid diethyl ester

Base Information

Chemical Name:[6-(3-methoxyphenyl)-8-naphthalen-1-yl-quinolin-2-yl]phosphonic acid diethyl ester
CAS No.:1185410-79-0
Molecular Formula:C₃₀H₂₈NO₄P
Molecular Weight:497.53
Hs Code.:

Synonyms:[6-(3-methoxyphenyl)-8-naphthalen-1-yl-quinolin-2-yl]phosphonic acid diethyl ester

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Chemical Property of [6-(3-methoxyphenyl)-8-naphthalen-1-yl-quinolin-2-yl]phosphonic acid diethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of [6-(3-methoxyphenyl)-8-naphthalen-1-yl-quinolin-2-yl]phosphonic acid diethyl ester

There total 9 articles about [6-(3-methoxyphenyl)-8-naphthalen-1-yl-quinolin-2-yl]phosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1185410-76-7
2-chloro-6-(3-methoxyphenyl)-8-naphthalen-1-yl-quinoline

: 762-04-9
phosphonic acid diethyl ester

: 1185410-79-0
[6-(3-methoxyphenyl)-8-naphthalen-1-yl-quinolin-2-yl]phosphonic acid diethyl ester

Guidance literature:: With triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 100 ℃; for 21h; Inert atmosphere;

Reference yield:

: 1185410-34-7
8-bromo-6-nitro-1H-quinolin-2-one

: 1185410-79-0
[6-(3-methoxyphenyl)-8-naphthalen-1-yl-quinolin-2-yl]phosphonic acid diethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; N,N-dimethyl-formamide / 3 h / 92 °C / Inert atmosphere

2.1: hydrogen / nickel / tetrahydrofuran; methanol; ethanol

3.1: hydrogenchloride; sodium nitrite / water / 0.42 h / -16 °C

3.2: 20 °C

4.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; N,N-dimethyl-formamide / 1 h / 110 °C / Inert atmosphere

5.1: tetraethylammonium chloride; N,N-dimethyl-aniline; trichlorophosphate / acetonitrile / 0.5 h / 60 °C

6.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 21 h / 100 °C / Inert atmosphere

With hydrogenchloride; tetraethylammonium chloride; hydrogen; potassium carbonate; N,N-dimethyl-aniline; triethylamine; sodium nitrite; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; nickel; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1185410-74-5
6-(3-methoxyphenyl)-8-naphthalen-1-yl-1H-quinolin-2-one

: 1185410-79-0
[6-(3-methoxyphenyl)-8-naphthalen-1-yl-quinolin-2-yl]phosphonic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: tetraethylammonium chloride; N,N-dimethyl-aniline; trichlorophosphate / acetonitrile / 0.5 h / 60 °C

2: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 21 h / 100 °C / Inert atmosphere

With tetraethylammonium chloride; N,N-dimethyl-aniline; triethylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; acetonitrile;