3-iodomethyl-3-methyl-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indole

Base Information

• Chemical Name: 3-iodomethyl-3-methyl-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indole
• CAS No.: 1266570-75-5
• Molecular Formula: C₁₇H₁₈INO₂S
• Molecular Weight: 427.306
• Mol file: 1266570-75-5.mol

Synonyms:3-iodomethyl-3-methyl-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indole

Chemical Property of 3-iodomethyl-3-methyl-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-iodomethyl-3-methyl-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indole

There total 3 articles about 3-iodomethyl-3-methyl-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-(2-iodophenyl)-4-methyl-N-(2-methylallyl)benzenesulfonamide → 3-iodomethyl-3-methyl-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indole (1266570-75-5)

Guidance literature:

With Pd(Q-Phos)₂; In toluene; at 100 ℃; for 4h; Inert atmosphere;

DOI:10.1021/ja110377q

Reference yield: 91.0%

2-bromo-N-tosyl-N-(2-methylallyl)aniline (1191913-83-3) → 3-iodomethyl-3-methyl-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indole (1266570-75-5)

Guidance literature:

With Pd(Q-Phos)2; potassium iodide; In toluene; at 100 ℃; for 16h; Inert atmosphere;

DOI:10.1021/ja206099t

Reference yield:

N-tosyl-2-iodoaniline (61613-20-5) → 3-iodomethyl-3-methyl-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indole (1266570-75-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0 °C

1.2: 2 h / 0 - 20 °C

2.1: C₅₀H₄₄Au₂P₄⁽²⁺⁾*2C₂F₆NO₄S₂^(1-) / acetonitrile; water / 0.25 h / Inert atmosphere; Sealed tube; UV-irradiation

With C₅₀H₄₄Au₂P₄⁽²⁺⁾*2C₂F₆NO₄S₂^(1-); sodium hydride; In water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

DOI:10.1021/acs.orglett.0c03030

upstream raw materials:

2-bromo-N-tosyl-N-(2-methylallyl)aniline

N-tosyl-2-iodoaniline