5-Methylpyrrolo[1,2-A]thieno[3,2-E]pyrazine

Base Information

• Chemical Name: 5-Methylpyrrolo[1,2-A]thieno[3,2-E]pyrazine
• CAS No.: 95502-68-4
• Molecular Formula: C₁₀H₈N₂S
• Molecular Weight: 188.253
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID40538872
• Wikidata: Q82414439
• Mol file: 95502-68-4.mol

Synonyms:5-METHYLPYRROLO[1,2-A]THIENO[3,2-E]PYRAZINE;95502-68-4;DTXSID40538872;8-methyl-3-thia-1,7-diazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaene

Chemical Property of 5-Methylpyrrolo[1,2-A]thieno[3,2-E]pyrazine

Chemical Property:

• PSA: 45.54000
• LogP: 2.85740
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 188.04081944
• Heavy Atom Count: 13
• Complexity: 209

Purity/Quality:

5-methyl-Pyrrolo[1,2-a]thieno[3,2-e]pyrazine 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC2=C(N3C1=CC=C3)SC=C2

Technology Process of 5-Methylpyrrolo[1,2-A]thieno[3,2-E]pyrazine

There total 3 articles about 5-Methylpyrrolo[1,2-A]thieno[3,2-E]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

Benzoyl-4 cyano-5 methyl-5 pyrrolo<1,2-a>thieno<3,2-e>pyrazine (95502-66-2) → Methyl-5 pyrrolo<1,2-a>thieno<3,2-e>pyrazine (95502-68-4)

Guidance literature:

With potassium hydroxide; ethanol; for 1.5h; Heating;

DOI:10.1002/jhet.5570210545

Reference yield:

Dihydro-4,5 benzoyl-4 cyano-5 pyrrolo<1,2-a>thieno<3,2-e>pyrazine (95502-64-0) → Methyl-5 pyrrolo<1,2-a>thieno<3,2-e>pyrazine (95502-68-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / NaH / dimethylformamide; petroleum ether / 2.5 h / 0 - 5 °C

2: 85 percent / aq. KOH, C₂H₅OH / 1.5 h / Heating

With potassium hydroxide; ethanol; sodium hydride; In N,N-dimethyl-formamide; Petroleum ether;

DOI:10.1002/jhet.5570210545

Reference yield:

Pyrrolo<1,2-a>thieno<3,2-e>pyrazine (75214-39-0) → Methyl-5 pyrrolo<1,2-a>thieno<3,2-e>pyrazine (95502-68-4)

Guidance literature:

Multi-step reaction with 3 steps

2: 92 percent / NaH / dimethylformamide; petroleum ether / 2.5 h / 0 - 5 °C

3: 85 percent / aq. KOH, C₂H₅OH / 1.5 h / Heating

With potassium hydroxide; ethanol; sodium hydride; In N,N-dimethyl-formamide; Petroleum ether;

DOI:10.1002/jhet.5570210545

upstream raw materials:

Benzoyl-4 cyano-5 methyl-5 pyrrolo<1,2-a>thieno<3,2-e>pyrazine

Dihydro-4,5 benzoyl-4 cyano-5 pyrrolo<1,2-a>thieno<3,2-e>pyrazine

Pyrrolo<1,2-a>thieno<3,2-e>pyrazine