1-benzyl-5-(phenylsulfonyl)-6-<1-benzyloxymethyl-3-hydroxypropyl>-2-piperidone

Base Information

Chemical Name:1-benzyl-5-(phenylsulfonyl)-6-<1-benzyloxymethyl-3-hydroxypropyl>-2-piperidone
CAS No.:163041-41-6
Molecular Formula:C₂₉H₃₃NO₆S
Molecular Weight:523.65
Hs Code.:

Synonyms:1-benzyl-5-(phenylsulfonyl)-6-<1-benzyloxymethyl-3-hydroxypropyl>-2-piperidone

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Chemical Property of 1-benzyl-5-(phenylsulfonyl)-6-<1-benzyloxymethyl-3-hydroxypropyl>-2-piperidone

Chemical Property:

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Technology Process of 1-benzyl-5-(phenylsulfonyl)-6-<1-benzyloxymethyl-3-hydroxypropyl>-2-piperidone

There total 1 articles about 1-benzyl-5-(phenylsulfonyl)-6-<1-benzyloxymethyl-3-hydroxypropyl>-2-piperidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6178-52-5
4-(phenylsulfonyl)butanoic acid

: N-benzylidene, 2-(S)-benzyloxymethylether-4-hydroxybutanal

: 163041-41-6
1-benzyl-5-(phenylsulfonyl)-6-<1-benzyloxymethyl-3-hydroxypropyl>-2-piperidone

: (5S,6R)-5-Benzenesulfonyl-1-benzyl-6-((S)-1-benzyloxymethoxy-3-hydroxy-propyl)-piperidin-2-one

Guidance literature:: With n-butyllithium; boron trifluoride diethyl etherate; In tetrahydrofuran; at -78 - 0 ℃; Yield given. Yields of byproduct given;
DOI:10.1016/0040-4020(95)00037-9

Reference yield:

: 163041-41-6
1-benzyl-5-(phenylsulfonyl)-6-<1-benzyloxymethyl-3-hydroxypropyl>-2-piperidone

: 163041-46-1
1-hydroxy-8-(phenylsulfonyl)-indolizidine

Guidance literature:: Multi-step reaction with 3 steps

1: 1M BH₃*THF / tetrahydrofuran / 0 - 20 °C

2: 1.) K₂CO₃, TEA, MsCl, 2.) H₂ / 2.) Pearlman's catalyst / 1.) CH₂Cl₂, RT, 2 h, 2.) MeOH, 39 psi

3: H₂, TFA / 10percent Pd/C / methanol / 10 h / 1034.3 Torr / Ambient temperature

With borane-THF; TEA; hydrogen; potassium carbonate; methanesulfonyl chloride; trifluoroacetic acid; palladium dihydroxide; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1016/0040-4020(95)00037-9

Reference yield:

: 163041-41-6
1-benzyl-5-(phenylsulfonyl)-6-<1-benzyloxymethyl-3-hydroxypropyl>-2-piperidone

: 163181-20-2
(1S,8S,8aR)-8-Benzenesulfonyl-octahydro-indolizin-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 1M BH₃*THF / tetrahydrofuran / 0 - 20 °C

2: 1.) K₂CO₃, TEA, MsCl, 2.) H₂ / 2.) Pearlman's catalyst / 1.) CH₂Cl₂, RT, 2 h, 2.) MeOH, 39 psi

3: H₂, TFA / 10percent Pd/C / methanol / 10 h / 1034.3 Torr / Ambient temperature

With borane-THF; TEA; hydrogen; potassium carbonate; methanesulfonyl chloride; trifluoroacetic acid; palladium dihydroxide; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1016/0040-4020(95)00037-9