Phenylmethyl cis,rac-<1-<(2,4-Dimethoxyphenyl)-methyl>-2-(fluoromethyl)-4-oxo-3-azetidinyl>carbamate

Base Information

• Chemical Name: Phenylmethyl cis,rac-<1-<(2,4-Dimethoxyphenyl)-methyl>-2-(fluoromethyl)-4-oxo-3-azetidinyl>carbamate
• CAS No.: 88946-31-0
• Molecular Formula: C₂₁H₂₃FN₂O₅
• Molecular Weight: 402.422

Synonyms:Phenylmethyl cis,rac-<1-<(2,4-Dimethoxyphenyl)-methyl>-2-(fluoromethyl)-4-oxo-3-azetidinyl>carbamate

Chemical Property of Phenylmethyl cis,rac-<1-<(2,4-Dimethoxyphenyl)-methyl>-2-(fluoromethyl)-4-oxo-3-azetidinyl>carbamate

Chemical Property:

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Technology Process of Phenylmethyl cis,rac-<1-<(2,4-Dimethoxyphenyl)-methyl>-2-(fluoromethyl)-4-oxo-3-azetidinyl>carbamate

There total 3 articles about Phenylmethyl cis,rac-<1-<(2,4-Dimethoxyphenyl)-methyl>-2-(fluoromethyl)-4-oxo-3-azetidinyl>carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2,4-Dimethoxy-benzyl)-[2-fluoro-eth-(Z)-ylidene]-amine → Phenylmethyl cis,rac-<1-<(2,4-Dimethoxyphenyl)-methyl>-2-(fluoromethyl)-4-oxo-3-azetidinyl>carbamate (88946-31-0)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / CH₂Cl₂ / Ambient temperature

2: 0.96 g / methylhydrazine / 1,2-dimethoxy-ethane / 1.5 h / Ambient temperature

3: propylene oxide / CH₂Cl₂ / 2.5 h / Ambient temperature

With triethylamine; methylhydrazine; methyloxirane; In 1,2-dimethoxyethane; dichloromethane;

DOI:10.1021/jo00182a021

Reference yield:

cis,rac-2-<1-<(2,4-Dimethoxyphenyl)methyl>-2-(fluoromethyl)-4-oxo-3-azetidinyl>-1H-isoindole-1,3(2H)-dione (88946-30-9) → Phenylmethyl cis,rac-<1-<(2,4-Dimethoxyphenyl)-methyl>-2-(fluoromethyl)-4-oxo-3-azetidinyl>carbamate (88946-31-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.96 g / methylhydrazine / 1,2-dimethoxy-ethane / 1.5 h / Ambient temperature

2: propylene oxide / CH₂Cl₂ / 2.5 h / Ambient temperature

With methylhydrazine; methyloxirane; In 1,2-dimethoxyethane; dichloromethane;

DOI:10.1021/jo00182a021

Reference yield:

cis-3-AMINO-4-(FLUOROMETHYL)-1-(2,4-DIMETHOXYBENZYL)-2-AZETIDINONE (88946-38-7) + benzyl chloroformate (501-53-1,94274-21-2) → Phenylmethyl cis,rac-<1-<(2,4-Dimethoxyphenyl)-methyl>-2-(fluoromethyl)-4-oxo-3-azetidinyl>carbamate (88946-31-0)

Guidance literature:

With methyloxirane; In dichloromethane; for 2.5h; Yield given; Ambient temperature;

DOI:10.1021/jo00182a021

upstream raw materials:

cis-3-AMINO-4-(FLUOROMETHYL)-1-(2,4-DIMETHOXYBENZYL)-2-AZETIDINONE

benzyl chloroformate

cis,rac-2-<1-<(2,4-Dimethoxyphenyl)methyl>-2-(fluoromethyl)-4-oxo-3-azetidinyl>-1H-isoindole-1,3(2H)-dione

Downstream raw materials:

Phenylmethyl cis,rac-<2-(Fluoromethyl)-4-oxo-3-azetidinyl>carbamate

Sodium cis,rac-2-(Fluoromethyl)-4-oxo-3-<<(phenylmethoxy)carbonyl>amino>-1-azetidinesulfonate

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