5-ethoxy-2-(pyridin-2-yl)phenol

Base Information

• Chemical Name: 5-ethoxy-2-(pyridin-2-yl)phenol
• CAS No.: 1452876-13-9
• Molecular Formula: C₁₃H₁₃NO₂
• Molecular Weight: 215.252

Synonyms:5-ethoxy-2-(pyridin-2-yl)phenol

Chemical Property of 5-ethoxy-2-(pyridin-2-yl)phenol

Chemical Property:

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Technology Process of 5-ethoxy-2-(pyridin-2-yl)phenol

There total 4 articles about 5-ethoxy-2-(pyridin-2-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2-(p-ethoxyphenyl)pyridine (4357-28-2) → 5-ethoxy-2-(pyridin-2-yl)phenol (1452876-13-9)

Guidance literature:

With N-hydroxyphthalimide; oxygen; palladium dichloride; In toluene; at 100 ℃; for 15h; under 760.051 Torr; Schlenk technique;

DOI:10.1002/anie.201300957

Reference yield:

2-bromo-pyridine (109-04-6) → 5-ethoxy-2-(pyridin-2-yl)phenol (1452876-13-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene; ethanol / 12 h / 120 °C / Inert atmosphere; Schlenk technique

2.1: C₂₈H₃₈ClN₂O₂Rh; sodium methylate / benzene / 0.17 h / Glovebox; Schlenk technique; Inert atmosphere

2.2: 16 h / 80 °C / Schlenk technique; Sealed tube; Inert atmosphere

3.1: Oxone / water; acetone

With Oxone; tetrakis(triphenylphosphine) palladium⁽⁰⁾; C₂₈H₃₈ClN₂O₂Rh; sodium methylate; sodium carbonate; In ethanol; water; acetone; toluene; benzene;

DOI:10.1039/c8cc03144d

Reference yield:

(4-ethoxyphenyl)boronic acid (22237-13-4) → 5-ethoxy-2-(pyridin-2-yl)phenol (1452876-13-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene; ethanol / 12 h / 120 °C / Inert atmosphere; Schlenk technique

2.1: C₂₈H₃₈ClN₂O₂Rh; sodium methylate / benzene / 0.17 h / Glovebox; Schlenk technique; Inert atmosphere

2.2: 16 h / 80 °C / Schlenk technique; Sealed tube; Inert atmosphere

3.1: Oxone / water; acetone

With Oxone; tetrakis(triphenylphosphine) palladium⁽⁰⁾; C₂₈H₃₈ClN₂O₂Rh; sodium methylate; sodium carbonate; In ethanol; water; acetone; toluene; benzene;

DOI:10.1039/c8cc03144d

upstream raw materials:

2-(p-ethoxyphenyl)pyridine

2-bromo-pyridine

(4-ethoxyphenyl)boronic acid

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