{1-[(dimethylamino)methyl]cyclobutyl}methyl 4-aminobenzoate

Base Information

• Chemical Name: {1-[(dimethylamino)methyl]cyclobutyl}methyl 4-aminobenzoate
• CAS No.: 39943-31-2
• Molecular Formula: C15H22 N2 O2
• Molecular Weight: 262.3474
• Mol file: 39943-31-2.mol

Synonyms:Cyclobutanemethanol,1-[(dimethylamino)methyl]-, 4-aminobenzoate (ester) (9CI); NSC 171635

Chemical Property of {1-[(dimethylamino)methyl]cyclobutyl}methyl 4-aminobenzoate

Chemical Property:

• Vapor Pressure: 1.07E-06mmHg at 25°C
• Boiling Point: 402.8°C at 760 mmHg
• Flash Point: 197.4°C
• Density: 1.109g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of {1-[(dimethylamino)methyl]cyclobutyl}methyl 4-aminobenzoate

There total 2 articles about {1-[(dimethylamino)methyl]cyclobutyl}methyl 4-aminobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Nitro-benzoic acid 1-dimethylaminomethyl-cyclobutylmethyl ester (39980-82-0) → 4-Amino-benzoic acid 1-dimethylaminomethyl-cyclobutylmethyl ester (39943-31-2)

Guidance literature:

With hydrogen; platinum(IV) oxide; In ethanol;

DOI:10.1021/jm00280a001

Reference yield:

1-(N,N-dimethylaminomethyl)-1-(hydroxymethyl)cyclobutane (39943-42-5) → 4-Amino-benzoic acid 1-dimethylaminomethyl-cyclobutylmethyl ester (39943-31-2)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) NaH, benzene, (ii) /BRN= 1912198/

2: H₂ / PtO₂ / ethanol

With hydrogen; platinum(IV) oxide; In ethanol;

DOI:10.1021/jm00280a001

upstream raw materials:

4-Nitro-benzoic acid 1-dimethylaminomethyl-cyclobutylmethyl ester

1-(N,N-dimethylaminomethyl)-1-(hydroxymethyl)cyclobutane

Refernces