tert-butyl (2R,6R)-1-(tert-butyldiphenylsilyloxy)-6,9-dihydroxynonan-2-ylcarbamate

Base Information

Chemical Name:tert-butyl (2R,6R)-1-(tert-butyldiphenylsilyloxy)-6,9-dihydroxynonan-2-ylcarbamate
CAS No.:1345017-66-4
Molecular Formula:C₃₀H₄₇NO₅Si
Molecular Weight:529.792
Hs Code.:

Synonyms:tert-butyl (2R,6R)-1-(tert-butyldiphenylsilyloxy)-6,9-dihydroxynonan-2-ylcarbamate

Suppliers and Price of tert-butyl (2R,6R)-1-(tert-butyldiphenylsilyloxy)-6,9-dihydroxynonan-2-ylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl (2R,6R)-1-(tert-butyldiphenylsilyloxy)-6,9-dihydroxynonan-2-ylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl (2R,6R)-1-(tert-butyldiphenylsilyloxy)-6,9-dihydroxynonan-2-ylcarbamate

There total 4 articles about tert-butyl (2R,6R)-1-(tert-butyldiphenylsilyloxy)-6,9-dihydroxynonan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1345017-65-3
tert-butyl (R)-1-(tert-butyldiphenylsilyloxy)-5-((R)-5-oxo-tetrahydrofuran-2-yl)pentan-2-ylcarbamate

: 1345017-66-4
tert-butyl (2R,6R)-1-(tert-butyldiphenylsilyloxy)-6,9-dihydroxynonan-2-ylcarbamate

Guidance literature:: tert-butyl (R)-1-(tert-butyldiphenylsilyloxy)-5-((R)-5-oxo-tetrahydrofuran-2-yl)pentan-2-ylcarbamate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h; Inert atmosphere;

With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.tetlet.2011.08.084

Reference yield:

: 1345017-50-6
tert-butyl (2R,6R,E)-1-(tert-butyldiphenylsilyloxy)-6-hydroxyocta-3,7-dien-2-ylcarbamate

: 1345017-66-4
tert-butyl (2R,6R)-1-(tert-butyldiphenylsilyloxy)-6,9-dihydroxynonan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap; triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2.1: Grubbs catalyst first generation / dichloromethane / 24 h / 20 °C / Inert atmosphere

3.1: palladium on activated charcoal; hydrogen / ethyl acetate / 24 h / 20 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

4.2: 20 °C / Inert atmosphere

With Grubbs catalyst first generation; dmap; lithium aluminium tetrahydride; palladium on activated charcoal; hydrogen; triethylamine; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1016/j.tetlet.2011.08.084

Reference yield:

: 1345017-63-1
(3R,7R,E)-7-(tert-butoxycarbonylamino)-8-(tert-butyldiphenylsilyloxy)octa-1,5-dien-3-yl acrylate

: 1345017-66-4
tert-butyl (2R,6R)-1-(tert-butyldiphenylsilyloxy)-6,9-dihydroxynonan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: Grubbs catalyst first generation / dichloromethane / 24 h / 20 °C / Inert atmosphere

2.1: palladium on activated charcoal; hydrogen / ethyl acetate / 24 h / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With Grubbs catalyst first generation; lithium aluminium tetrahydride; palladium on activated charcoal; hydrogen; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1016/j.tetlet.2011.08.084