9-[2-O-acetyl-4-C-(benzoyloxymethyl)-5-O-(4,4'-dimethoxytrityl)-β-D-xylofuranosyl]-6-N-benzoyladenine

Base Information

Chemical Name:9-[2-O-acetyl-4-C-(benzoyloxymethyl)-5-O-(4,4'-dimethoxytrityl)-β-D-xylofuranosyl]-6-N-benzoyladenine
CAS No.:861230-98-0
Molecular Formula:C₄₈H₄₃N₅O₁₀
Molecular Weight:849.897
Hs Code.:

Synonyms:9-[2-O-acetyl-4-C-(benzoyloxymethyl)-5-O-(4,4'-dimethoxytrityl)-β-D-xylofuranosyl]-6-N-benzoyladenine

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Chemical Property of 9-[2-O-acetyl-4-C-(benzoyloxymethyl)-5-O-(4,4'-dimethoxytrityl)-β-D-xylofuranosyl]-6-N-benzoyladenine

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Technology Process of 9-[2-O-acetyl-4-C-(benzoyloxymethyl)-5-O-(4,4'-dimethoxytrityl)-β-D-xylofuranosyl]-6-N-benzoyladenine

There total 8 articles about 9-[2-O-acetyl-4-C-(benzoyloxymethyl)-5-O-(4,4'-dimethoxytrityl)-β-D-xylofuranosyl]-6-N-benzoyladenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 861230-96-8
9-[2-O-acetyl-4-C-(benzoyloxymethyl)-β-D-xylofuranosyl]-6-N-benzoyladenine

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 861230-98-0
9-[2-O-acetyl-4-C-(benzoyloxymethyl)-5-O-(4,4'-dimethoxytrityl)-β-D-xylofuranosyl]-6-N-benzoyladenine

Guidance literature:: With pyridine; at 20 ℃; for 12h;
DOI:10.1002/ejoc.200500023

Reference yield:

: 72261-44-0
1,2-O-isopropylidene-3-O-benzyl-4-C-(hydroxymethyl)-β-L-threo-pento-1,4-furanose

: 861230-98-0
9-[2-O-acetyl-4-C-(benzoyloxymethyl)-5-O-(4,4'-dimethoxytrityl)-β-D-xylofuranosyl]-6-N-benzoyladenine

Guidance literature:: Multi-step reaction with 8 steps

1: 89 percent / ammonium formate / Pd(OH)2/C / methanol / 16 h / Heating

2: 93 percent / triethylamine / CH₂Cl₂ / 36 h / 20 °C

3: 86 percent / pyridine / CH₂Cl₂ / 12 h / 0 - 20 °C

4: 93 percent / DMAP; imidazole / dimethylformamide / 12 h / 20 °C

5: 87 percent / H₂SO₄; acetic acid / 4 h / 20 °C

6: 66 percent / SnCl₄ / acetonitrile / 36 h / Heating

7: 52 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C

8: 88 percent / pyridine / 12 h / 20 °C

With pyridine; 1H-imidazole; dmap; sulfuric acid; tetrabutyl ammonium fluoride; ammonium formate; tin(IV) chloride; acetic acid; triethylamine; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/ejoc.200500023

Reference yield:

: 861230-89-9
5-O-(tert-butyldiphenylsilyl)-4-C-(hydroxymethyl)-1,2-O-isopropylidene-α-D-xylofuranose

: 861230-98-0
9-[2-O-acetyl-4-C-(benzoyloxymethyl)-5-O-(4,4'-dimethoxytrityl)-β-D-xylofuranosyl]-6-N-benzoyladenine

Guidance literature:: Multi-step reaction with 6 steps

1: 86 percent / pyridine / CH₂Cl₂ / 12 h / 0 - 20 °C

2: 93 percent / DMAP; imidazole / dimethylformamide / 12 h / 20 °C

3: 87 percent / H₂SO₄; acetic acid / 4 h / 20 °C

4: 66 percent / SnCl₄ / acetonitrile / 36 h / Heating

5: 52 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C

6: 88 percent / pyridine / 12 h / 20 °C

With pyridine; 1H-imidazole; dmap; sulfuric acid; tetrabutyl ammonium fluoride; tin(IV) chloride; acetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/ejoc.200500023