{3-[5-{(1R,2S)-1-Ethyl-2-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-butyl}-2-(tetrahydro-pyran-2-yloxy)-phenyl]-propyl}-(7-nitro-benzo[1,2,5]oxadiazol-4-yl)-amine

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Chemical Name:{3-[5-{(1R,2S)-1-Ethyl-2-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-butyl}-2-(tetrahydro-pyran-2-yloxy)-phenyl]-propyl}-(7-nitro-benzo[1,2,5]oxadiazol-4-yl)-amine
CAS No.:104946-89-6
Molecular Formula:C₃₇H₄₆N₄O₇
Molecular Weight:658.795
Hs Code.:

Synonyms:{3-[5-{(1R,2S)-1-Ethyl-2-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-butyl}-2-(tetrahydro-pyran-2-yloxy)-phenyl]-propyl}-(7-nitro-benzo[1,2,5]oxadiazol-4-yl)-amine

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Chemical Property of {3-[5-{(1R,2S)-1-Ethyl-2-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-butyl}-2-(tetrahydro-pyran-2-yloxy)-phenyl]-propyl}-(7-nitro-benzo[1,2,5]oxadiazol-4-yl)-amine

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Technology Process of {3-[5-{(1R,2S)-1-Ethyl-2-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-butyl}-2-(tetrahydro-pyran-2-yloxy)-phenyl]-propyl}-(7-nitro-benzo[1,2,5]oxadiazol-4-yl)-amine

There total 4 articles about {3-[5-{(1R,2S)-1-Ethyl-2-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-butyl}-2-(tetrahydro-pyran-2-yloxy)-phenyl]-propyl}-(7-nitro-benzo[1,2,5]oxadiazol-4-yl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 104946-83-0
3-[5-{(1R,2S)-1-Ethyl-2-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-butyl}-2-(tetrahydro-pyran-2-yloxy)-phenyl]-propan-1-ol

: 104946-89-6
{3-[5-{(1R,2S)-1-Ethyl-2-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-butyl}-2-(tetrahydro-pyran-2-yloxy)-phenyl]-propyl}-(7-nitro-benzo[1,2,5]oxadiazol-4-yl)-amine

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / pyridine / 8 h / 0 °C

2: 90 percent / dimethylformamide / 3 h / 70 °C

3: 100 percent / hydrazine hydrate / ethanol / 48 h / 25 °C

4: Et₃N / methanol / 4 h / Ambient temperature

With pyridine; hydrazine hydrate; triethylamine; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00384a026

Reference yield:

: 104946-85-2
(3R*,4S*)-3-<3-(3-phthalimidopropyl)-4-(2-tetrahydropyranyloxy)phenyl>-4-<4-(2-tetrahydropyranyloxy)phenyl>hexane

: 104946-89-6
{3-[5-{(1R,2S)-1-Ethyl-2-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-butyl}-2-(tetrahydro-pyran-2-yloxy)-phenyl]-propyl}-(7-nitro-benzo[1,2,5]oxadiazol-4-yl)-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / hydrazine hydrate / ethanol / 48 h / 25 °C

2: Et₃N / methanol / 4 h / Ambient temperature

With hydrazine hydrate; triethylamine; In methanol; ethanol;
DOI:10.1021/jm00384a026

Reference yield:

: 104946-84-1
(3R*,4S*)-3-<3-<3-(p-toluenesulfonyloxy)propyl>-4-(2-tetrahydropyranyloxy)phenyl>-4-<4-(2-tetrahydropyranyloxy)phenyl>hexane

: 104946-89-6
{3-[5-{(1R,2S)-1-Ethyl-2-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-butyl}-2-(tetrahydro-pyran-2-yloxy)-phenyl]-propyl}-(7-nitro-benzo[1,2,5]oxadiazol-4-yl)-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / dimethylformamide / 3 h / 70 °C

2: 100 percent / hydrazine hydrate / ethanol / 48 h / 25 °C

3: Et₃N / methanol / 4 h / Ambient temperature

With hydrazine hydrate; triethylamine; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00384a026