5-(2,2,2-trifluoroethoxymethyl)-5'-O-trityl-3',3'-difluoro-2',3'-dideoxyuridine

Base Information

Chemical Name:5-(2,2,2-trifluoroethoxymethyl)-5'-O-trityl-3',3'-difluoro-2',3'-dideoxyuridine
CAS No.:699007-51-7
Molecular Formula:C₃₁H₂₇F₅N₂O₅
Molecular Weight:602.558
Hs Code.:

Synonyms:5-(2,2,2-trifluoroethoxymethyl)-5'-O-trityl-3',3'-difluoro-2',3'-dideoxyuridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(2,2,2-trifluoroethoxymethyl)-5'-O-trityl-3',3'-difluoro-2',3'-dideoxyuridine

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Technology Process of 5-(2,2,2-trifluoroethoxymethyl)-5'-O-trityl-3',3'-difluoro-2',3'-dideoxyuridine

There total 4 articles about 5-(2,2,2-trifluoroethoxymethyl)-5'-O-trityl-3',3'-difluoro-2',3'-dideoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 699007-50-6
5-(2,2,2-trifluoroethoxymethyl)-5'-O-trityl-3'-keto-2',3'-dideoxyuridine

: 699007-51-7
5-(2,2,2-trifluoroethoxymethyl)-5'-O-trityl-3',3'-difluoro-2',3'-dideoxyuridine

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at 0 - 25 ℃;
DOI:10.1081/NCN-120027814

Reference yield:

: 699007-49-3
1-((2R,4S,5R)-4-Hydroxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-5-(2,2,2-trifluoro-ethoxymethyl)-1H-pyrimidine-2,4-dione

: 699007-51-7
5-(2,2,2-trifluoroethoxymethyl)-5'-O-trityl-3',3'-difluoro-2',3'-dideoxyuridine

Guidance literature:: Multi-step reaction with 2 steps

1: 0.25 g / pyridinium dichromate; molecular sieves / CH₂Cl₂ / 3 h

2: 52 percent / diethylaminosulfurtrifluoride / CH₂Cl₂ / 0 - 25 °C

With dipyridinium dichromate; molecular sieve; diethylamino-sulfur trifluoride; In dichloromethane;
DOI:10.1081/NCN-120027814

Reference yield:

: 76-83-5
trityl chloride

: 699007-51-7
5-(2,2,2-trifluoroethoxymethyl)-5'-O-trityl-3',3'-difluoro-2',3'-dideoxyuridine

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethylaminopyridine; pyridine / 25 °C

2: 0.25 g / pyridinium dichromate; molecular sieves / CH₂Cl₂ / 3 h

3: 52 percent / diethylaminosulfurtrifluoride / CH₂Cl₂ / 0 - 25 °C

With pyridine; dmap; dipyridinium dichromate; molecular sieve; diethylamino-sulfur trifluoride; In dichloromethane;
DOI:10.1081/NCN-120027814