1-methyl-1,4,5,6-tetrahydro-cyclopentapyrazole-3-carboxylic acid

Base Information

• Chemical Name: 1-methyl-1,4,5,6-tetrahydro-cyclopentapyrazole-3-carboxylic acid
• CAS No.: 854405-75-7
• Molecular Formula: C₈H₁₀N₂O₂
• Molecular Weight: 166.18
• Mol file: 854405-75-7.mol

Synonyms:1-methyl-1,4,5,6-tetrahydro-cyclopentapyrazole-3-carboxylic acid

Chemical Property of 1-methyl-1,4,5,6-tetrahydro-cyclopentapyrazole-3-carboxylic acid

Chemical Property:

• Boiling Point: 358.2±42.0 °C(Predicted)
• PKA: 3.94±0.20(Predicted)
• Density: 1.46±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

1-Methyl-1,4,5,6-tetrahydro-cyclopentapyrazole-3-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-methyl-1,4,5,6-tetrahydro-cyclopentapyrazole-3-carboxylic acid

There total 2 articles about 1-methyl-1,4,5,6-tetrahydro-cyclopentapyrazole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

oxo-(2-oxo-cyclopentyl)-acetic acid ethyl ester (39163-39-8) + methylhydrazine sulfuric acid (302-15-8) → 1-methyl-1,4,5,6-tetrahydro-cyclopentapyrazole-3-carboxylic acid (854405-75-7) + 2-methyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxylic acid (129560-01-6)

Guidance literature:

With ethanol; sodium acetate; Behandeln des Reaktionsprodukts mit aethanol.NaOH oder KOH;

Reference yield:

cyclopentanone (120-92-3) → 1-methyl-1,4,5,6-tetrahydro-cyclopentapyrazole-3-carboxylic acid (854405-75-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanolic sodium ethylate

2: sodium acetate; aqueous ethanol / Behandeln des Reaktionsprodukts mit aethanol.NaOH oder KOH

With ethanol; sodium ethanolate; sodium acetate;

Reference yield: 92.0%

1-methyl-1,4,5,6-tetrahydro-cyclopentapyrazole-3-carboxylic acid (854405-75-7) + (2-nitrobenzyl)methylamine (56222-08-3) → N-methyl-N-(2-nitrobenzyl)-1-methyl-1,4,5,6-tetrahydro-3-cyclopentapyrazolecarboxamide (868783-49-7)

Guidance literature:

With 2-chloro-1-methyl-pyridinium iodide; triethylamine; In tetrahydrofuran; at 20 ℃; for 5h;

upstream raw materials:

oxo-(2-oxo-cyclopentyl)-acetic acid ethyl ester

methylhydrazine sulfuric acid

cyclopentanone

Downstream raw materials:

N-methyl-N-(2-nitrobenzyl)-1-methyl-1,4,5,6-tetrahydro-3-cyclopentapyrazolecarboxamide

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