Technology Process of (S)-2-(4-bromophenyl)-2,3-dihydrobenzo[b][1,4]dioxine
There total 8 articles about (S)-2-(4-bromophenyl)-2,3-dihydrobenzo[b][1,4]dioxine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
C37H42IrNOPRu(1+)*C32H12BF24(1-); hydrogen;
In
dichloromethane;
at 20 ℃;
for 12h;
under 22502.3 Torr;
Overall yield = 92 %; enantioselective reaction;
Autoclave;
DOI:10.1016/j.tet.2017.12.015
- Guidance literature:
-
With
di-isopropyl azodicarboxylate; triphenylphosphine;
In
tetrahydrofuran;
at 0 - 25 ℃;
for 1.5h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: caesium carbonate / acetone / 1 h / 25 °C / Inert atmosphere
2: dmap; triethylamine / tetrahydrofuran / 0.75 h / 40 °C / Inert atmosphere
3: formic acid-triethylamine complex / N-[(1S,2S)-2-amino-1,2-diphenylethyl]-4-methylbenzenesulfonamide; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer / N,N-dimethyl-formamide / 2 h / 0 °C / Inert atmosphere
4: water; lithium hydroxide monohydrate / methanol / 0.5 h / 60 °C
5: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1.5 h / 0 - 25 °C / Inert atmosphere
With
dmap; lithium hydroxide monohydrate; di-isopropyl azodicarboxylate; formic acid-triethylamine complex; water; caesium carbonate; triethylamine; triphenylphosphine;
dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; N-[(1S,2S)-2-amino-1,2-diphenylethyl]-4-methylbenzenesulfonamide;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetone;
5: Mitsunobu reaction;
![2-(4-bromophenyl)benzo[b][1,4]dioxine](/Databaselist/images/loading.webp)
