4-[2-(2,6-difluorophenyl)-1H-indol-5-yl]-3-chloromethylbenzoic acid methyl ester

Base Information

Chemical Name:4-[2-(2,6-difluorophenyl)-1H-indol-5-yl]-3-chloromethylbenzoic acid methyl ester
CAS No.:1279104-25-4
Molecular Formula:C₂₂H₁₄ClF₂NO₂
Molecular Weight:397.808
Hs Code.:

Synonyms:4-[2-(2,6-difluorophenyl)-1H-indol-5-yl]-3-chloromethylbenzoic acid methyl ester

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Chemical Property of 4-[2-(2,6-difluorophenyl)-1H-indol-5-yl]-3-chloromethylbenzoic acid methyl ester

Chemical Property:

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Technology Process of 4-[2-(2,6-difluorophenyl)-1H-indol-5-yl]-3-chloromethylbenzoic acid methyl ester

There total 5 articles about 4-[2-(2,6-difluorophenyl)-1H-indol-5-yl]-3-chloromethylbenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 1279106-83-0
4-[1-benzenesulfonyl-2-(2,6-difluoro-phenyl)-1H-indol-5-yl]-3-chloro-benzoic acid methyl ester

: 1279104-25-4
4-[2-(2,6-difluorophenyl)-1H-indol-5-yl]-3-chloromethylbenzoic acid methyl ester

Guidance literature:: With methanol; caesium carbonate; In tetrahydrofuran; at 25 ℃; for 24h;

Reference yield:

: 13670-99-0
2,6-difluoroacetophenone

: 1279104-25-4
4-[2-(2,6-difluorophenyl)-1H-indol-5-yl]-3-chloromethylbenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium acetate / ethanol / 16 h / 25 °C

2.1: polyphosphoric acid / 2 h / 130 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.2: 0 - 25 °C

4.1: potassium carbonate / 1,4-dioxane / 25 - 110 °C

5.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

6.1: methanol; caesium carbonate / tetrahydrofuran / 24 h / 25 °C

With methanol; potassium acetate; sodium hydride; potassium carbonate; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1188072-92-5
5-bromo-2-(2,6-difluoro-phenyl)-1H-indole

: 1279104-25-4
4-[2-(2,6-difluorophenyl)-1H-indol-5-yl]-3-chloromethylbenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 0 - 25 °C

2.1: potassium carbonate / 1,4-dioxane / 25 - 110 °C

3.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

4.1: methanol; caesium carbonate / tetrahydrofuran / 24 h / 25 °C

With methanol; sodium hydride; potassium carbonate; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;