(Z)-4-Dimethylamino-3-phenylsulfanyl-1-(2,2,2-trichloro-ethoxy)-but-3-en-2-one

Base Information

• Chemical Name: (Z)-4-Dimethylamino-3-phenylsulfanyl-1-(2,2,2-trichloro-ethoxy)-but-3-en-2-one
• CAS No.: 115413-30-4
• Molecular Formula: C₁₄H₁₆Cl₃NO₂S
• Molecular Weight: 368.712
• Mol file: 115413-30-4.mol

Synonyms:(Z)-4-Dimethylamino-3-phenylsulfanyl-1-(2,2,2-trichloro-ethoxy)-but-3-en-2-one

Chemical Property of (Z)-4-Dimethylamino-3-phenylsulfanyl-1-(2,2,2-trichloro-ethoxy)-but-3-en-2-one

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-4-Dimethylamino-3-phenylsulfanyl-1-(2,2,2-trichloro-ethoxy)-but-3-en-2-one

There total 4 articles about (Z)-4-Dimethylamino-3-phenylsulfanyl-1-(2,2,2-trichloro-ethoxy)-but-3-en-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-Phenylsulfanyl-3-(2,2,2-trichloro-ethoxy)-propan-2-one (115413-21-3) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → (Z)-4-Dimethylamino-3-phenylsulfanyl-1-(2,2,2-trichloro-ethoxy)-but-3-en-2-one (115413-30-4)

Guidance literature:

at 70 ℃; for 1.5h;

DOI:10.1055/s-1987-28113

Reference yield:

2-(phenylsulfanylmethyl)oxirane (5296-21-9) → (Z)-4-Dimethylamino-3-phenylsulfanyl-1-(2,2,2-trichloro-ethoxy)-but-3-en-2-one (115413-30-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 15 percent / KOH / tetrahydrofuran; H₂O / 84 h / 70 °C

2: 50 percent / DMSO, dicyclohexylcarbodiimide (DCC), H₃PO₄ / 15 h / Ambient temperature

3: 100 percent / 1.5 h / 70 °C

With potassium hydroxide; phosphoric acid; dimethyl sulfoxide; dicyclohexyl-carbodiimide; In tetrahydrofuran; water;

DOI:10.1055/s-1987-28113

Reference yield:

potassium thiophenolate (3111-52-2) → (Z)-4-Dimethylamino-3-phenylsulfanyl-1-(2,2,2-trichloro-ethoxy)-but-3-en-2-one (115413-30-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 78 percent / aq. ethanol / 0.5 h

2: 15 percent / KOH / tetrahydrofuran; H₂O / 84 h / 70 °C

3: 50 percent / DMSO, dicyclohexylcarbodiimide (DCC), H₃PO₄ / 15 h / Ambient temperature

4: 100 percent / 1.5 h / 70 °C

With potassium hydroxide; phosphoric acid; dimethyl sulfoxide; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; water;

DOI:10.1055/s-1987-28113

upstream raw materials:

1-Phenylsulfanyl-3-(2,2,2-trichloro-ethoxy)-propan-2-one

N,N-dimethyl-formamide dimethyl acetal

2-(phenylsulfanylmethyl)oxirane

potassium thiophenolate

Downstream raw materials:

(Z)-4-Hydroxy-3-phenylsulfanyl-1-(2,2,2-trichloro-ethoxy)-but-3-en-2-one

Acetic acid (Z)-3-oxo-2-phenylsulfanyl-4-(2,2,2-trichloro-ethoxy)-but-1-enyl ester

Acetic acid (2R,4R)-2-ethoxy-5-phenylsulfanyl-6-(2,2,2-trichloro-ethoxymethyl)-3,4-dihydro-2H-pyran-4-yl ester

Acetic acid (2S,4R)-2-ethoxy-5-phenylsulfanyl-6-(2,2,2-trichloro-ethoxymethyl)-3,4-dihydro-2H-pyran-4-yl ester