3-Phenyl-1-(piperazin-1-yl)propan-1-one

Base Information

Chemical Name:3-Phenyl-1-(piperazin-1-yl)propan-1-one
CAS No.:117132-90-8
Molecular Formula:C₁₃H₁₈N₂O
Molecular Weight:218.299
Hs Code.:
European Community (EC) Number:960-447-0

Synonyms:3-phenyl-1-(piperazin-1-yl)propan-1-one;117132-90-8;3-phenyl-1-piperazin-1-ylpropan-1-one;1-(3-Phenylpropanoyl)piperazine;1-(3-phenylpropionyl)piperazine;SCHEMBL1838692;VBXKDEVTVQJYTD-UHFFFAOYSA-N;MFCD08442819;AKOS000125626;MCULE-1119685262;EN300-56535;Z228586876

Suppliers and Price of 3-Phenyl-1-(piperazin-1-yl)propan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 3-Phenyl-1-(piperazin-1-yl)propan-1-one

Chemical Property:

XLogP3:1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:218.141913202
Heavy Atom Count:16
Complexity:218

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCN1)C(=O)CCC2=CC=CC=C2

Technology Process of 3-Phenyl-1-(piperazin-1-yl)propan-1-one

There total 7 articles about 3-Phenyl-1-(piperazin-1-yl)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: tert-butyl 4-(3-phenylpropanoyl)piperazine-1-carboxylate

: 117132-90-8
1-(3-phenylpropionyl)piperazine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 23 ℃; for 12h; Inert atmosphere;
DOI:10.1021/jacs.5b12924

Reference yield:

: 110-85-0
piperazine

: 645-45-4
hydrocinnamic acid chloride

: 117132-90-8
1-(3-phenylpropionyl)piperazine

Guidance literature:: In acetic acid; at 20 ℃; Yield given;
DOI:10.1002/recl.19931120212

Reference yield:

: 501-52-0
3-Phenylpropionic acid

: 117132-90-8
1-(3-phenylpropionyl)piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 4 h / Reflux

2: acetic acid / chloroform / 3 h / 20 °C

With thionyl chloride; acetic acid; In chloroform;
DOI:10.3390/molecules21111544