(+/-)-1-<2-(methylamino)-2-(4-nitrophenyl)ethyl>pyrrolidine

Base Information

• Chemical Name: (+/-)-1-<2-(methylamino)-2-(4-nitrophenyl)ethyl>pyrrolidine
• CAS No.: 157948-03-3
• Molecular Formula: C₁₃H₁₉N₃O₂
• Molecular Weight: 249.313
• Mol file: 157948-03-3.mol

Synonyms:(+/-)-1-<2-(methylamino)-2-(4-nitrophenyl)ethyl>pyrrolidine

Chemical Property of (+/-)-1-<2-(methylamino)-2-(4-nitrophenyl)ethyl>pyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (+/-)-1-<2-(methylamino)-2-(4-nitrophenyl)ethyl>pyrrolidine

There total 9 articles about (+/-)-1-<2-(methylamino)-2-(4-nitrophenyl)ethyl>pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1-<2-(4-nitrophenyl)-2-formamidoethyl>pyrrolidine (157948-02-2) → (+/-)-1-<2-(methylamino)-2-(4-nitrophenyl)ethyl>pyrrolidine (157948-03-3)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; for 2h; Heating;

DOI:10.1021/jm00044a006

Reference yield: 49.7%

(+/-)-methyl N-<(4-nitrophenyl)(1-pyrrolidinylcarbonyl)methyl>carbamate (192188-04-8) → (+/-)-1-<2-(methylamino)-2-(4-nitrophenyl)ethyl>pyrrolidine (157948-03-3)

Guidance literature:

With borane-THF; In tetrahydrofuran; for 96h; Heating;

DOI:10.1021/jm00052a008

Reference yield:

2-amino-2-(4-nitrophenyl)acetic acid (5407-25-0) → (+/-)-1-<2-(methylamino)-2-(4-nitrophenyl)ethyl>pyrrolidine (157948-03-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 86 percent / aq. NaOH / 17 h / 25 °C

2: dicyclohexylcarbodiimide / CH₂Cl₂ / 1 h

3: CH₂Cl₂ / 120 h / 25 °C

4: 49.7 percent / BH₃*THF / tetrahydrofuran / 96 h / Heating

With sodium hydroxide; borane-THF; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00052a008

upstream raw materials:

1-<2-(4-nitrophenyl)-2-formamidoethyl>pyrrolidine

(+/-)-methyl N-<(4-nitrophenyl)(1-pyrrolidinylcarbonyl)methyl>carbamate

2-amino-2-(4-nitrophenyl)acetic acid

(+/-)-N-(methoxycarbonyl)-2-(4-nitrophenyl)glycine

Downstream raw materials:

N-methyl-N-<(1S)-1-(4-nitrophenyl)-2-(1-pyrrolidinyl)ethyl>-(S)-α-acetoxyphenylacetamide

2-(3,4-dichlorophenyl)-N-methyl-N-<(1R,S)-1-(4-nitrophenyl)-2-(1-pyrrolidinyl)ethyl>acetamide

2-(3,4-dichlorophenyl)-N-methyl-N-<(1R,S)-1-(4-aminophenyl)-2-(1-pyrrolidinyl)ethyl>acetamide

1-<(2S)-2-(4-nitrophenyl)-2-(methylamino)ethyl>pyrrolidine