N-[4-(tert-butyl(dimethyl)silyloxy)-1-butynyl]-N-phenylcarbamic acid methyl ester

Base Information

• Chemical Name: N-[4-(tert-butyl(dimethyl)silyloxy)-1-butynyl]-N-phenylcarbamic acid methyl ester
• CAS No.: 865081-73-8
• Molecular Formula: C₁₈H₂₇NO₃Si
• Molecular Weight: 333.503
• Mol file: 865081-73-8.mol

Synonyms:N-[4-(tert-butyl(dimethyl)silyloxy)-1-butynyl]-N-phenylcarbamic acid methyl ester

Chemical Property of N-[4-(tert-butyl(dimethyl)silyloxy)-1-butynyl]-N-phenylcarbamic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-[4-(tert-butyl(dimethyl)silyloxy)-1-butynyl]-N-phenylcarbamic acid methyl ester

There total 1 articles about N-[4-(tert-butyl(dimethyl)silyloxy)-1-butynyl]-N-phenylcarbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

N-phenyl methyl carbamate (2603-10-3) + (4-bromobut-3-ynyloxy)(tert-butyl)dimethylsilane (448944-55-6) → N-[4-(tert-butyl(dimethyl)silyloxy)-1-butynyl]-N-phenylcarbamic acid methyl ester (865081-73-8)

Guidance literature:

With potassium hexamethylsilazane; copper(l) iodide; 1,10-Phenanthroline; In toluene; at 90 ℃; for 12h;

DOI:10.1021/ol0512841

Reference yield: 78.0%

N-[4-(tert-butyl(dimethyl)silyloxy)-1-butynyl]-N-phenylcarbamic acid methyl ester (865081-73-8) + norborn-2-ene (498-66-8) → {(1S,2R,5S,6R)-4-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-tricyclo[4.2.1.02,5]non-3-en-3-yl}-phenyl-carbamic acid methyl ester

Guidance literature:

chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II); In tetrahydrofuran; at 60 ℃; for 72h;

DOI:10.1021/ol0512841

Reference yield: 25.0%

N-[4-(tert-butyl(dimethyl)silyloxy)-1-butynyl]-N-phenylcarbamic acid methyl ester (865081-73-8) + norborn-2-ene (498-66-8) → [(1S,2R,5S,6R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-tricyclo[4.2.1.02,5]non-3-en-3-yl]-phenyl-carbamic acid methyl ester

Guidance literature:

With chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II); In tetrahydrofuran; at 60 ℃; for 72h;

DOI:10.1016/j.tet.2005.11.081

upstream raw materials:

N-phenyl methyl carbamate

(4-bromobut-3-ynyloxy)(tert-butyl)dimethylsilane