N₄-(2'-chlorophenyl)-N₂-(4'-carboxyphenyl)-N₄-ethylpyrimidine-2,4-diamine hydrochloride

Base Information

• Chemical Name: N₄-(2'-chlorophenyl)-N₂-(4'-carboxyphenyl)-N₄-ethylpyrimidine-2,4-diamine hydrochloride
• CAS No.: 1395885-76-3
• Molecular Formula: C₁₉H₁₇ClN₄O₂*ClH
• Molecular Weight: 405.284

Synonyms:N₄-(2'-chlorophenyl)-N₂-(4'-carboxyphenyl)-N₄-ethylpyrimidine-2,4-diamine hydrochloride

Chemical Property of N₄-(2'-chlorophenyl)-N₂-(4'-carboxyphenyl)-N₄-ethylpyrimidine-2,4-diamine hydrochloride

Chemical Property:

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Technology Process of N₄-(2'-chlorophenyl)-N₂-(4'-carboxyphenyl)-N₄-ethylpyrimidine-2,4-diamine hydrochloride

There total 4 articles about N₄-(2'-chlorophenyl)-N₂-(4'-carboxyphenyl)-N₄-ethylpyrimidine-2,4-diamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

N4-(2-chlorophenyl)-N4-ethyl-2-chloropyrimidine-4-amine (1395887-04-3) + 4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → N4-(2'-chlorophenyl)-N2-(4'-carboxyphenyl)-N4-ethylpyrimidine-2,4-diamine hydrochloride (1395885-76-3)

Guidance literature:

In ethanol; at 150 ℃; for 0.333333h; Microwave irradiation;

DOI:10.1021/jm300334d

Reference yield:

N4-(2-chlorophenyl)-2-chloropyrimidine-4-amine (260046-05-7) → N4-(2'-chlorophenyl)-N2-(4'-carboxyphenyl)-N4-ethylpyrimidine-2,4-diamine hydrochloride (1395885-76-3)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / acetonitrile / 72 h / 20 °C

2: ethanol / 0.33 h / 150 °C / Microwave irradiation

With caesium carbonate; In ethanol; acetonitrile;

DOI:10.1021/jm300334d

Reference yield:

o-chloroaniline (95-51-2) → N4-(2'-chlorophenyl)-N2-(4'-carboxyphenyl)-N4-ethylpyrimidine-2,4-diamine hydrochloride (1395885-76-3)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / water / 72 h / 20 °C

2: caesium carbonate / acetonitrile / 72 h / 20 °C

3: ethanol / 0.33 h / 150 °C / Microwave irradiation

With hydrogenchloride; caesium carbonate; In ethanol; water; acetonitrile;

DOI:10.1021/jm300334d

upstream raw materials:

N⁴-(2-chlorophenyl)-2-chloropyrimidine-4-amine

N⁴-(2-chlorophenyl)-N⁴-ethyl-2-chloropyrimidine-4-amine

4-amino-benzoic acid

o-chloroaniline

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