(1S,2R,4S,6S)-6-Benzyloxy-2-(2-hydroxy-ethyl)-1-(2-phenyl-[1,3]dithian-2-ylmethyl)-2-triethylsilanyloxy-4-triisopropylsilanyloxy-cyclohexanol

Base Information

Chemical Name:(1S,2R,4S,6S)-6-Benzyloxy-2-(2-hydroxy-ethyl)-1-(2-phenyl-[1,3]dithian-2-ylmethyl)-2-triethylsilanyloxy-4-triisopropylsilanyloxy-cyclohexanol
CAS No.:874350-04-6
Molecular Formula:C₄₁H₆₈O₅S₂Si₂
Molecular Weight:761.291
Hs Code.:

Synonyms:(1S,2R,4S,6S)-6-Benzyloxy-2-(2-hydroxy-ethyl)-1-(2-phenyl-[1,3]dithian-2-ylmethyl)-2-triethylsilanyloxy-4-triisopropylsilanyloxy-cyclohexanol

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Chemical Property of (1S,2R,4S,6S)-6-Benzyloxy-2-(2-hydroxy-ethyl)-1-(2-phenyl-[1,3]dithian-2-ylmethyl)-2-triethylsilanyloxy-4-triisopropylsilanyloxy-cyclohexanol

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Technology Process of (1S,2R,4S,6S)-6-Benzyloxy-2-(2-hydroxy-ethyl)-1-(2-phenyl-[1,3]dithian-2-ylmethyl)-2-triethylsilanyloxy-4-triisopropylsilanyloxy-cyclohexanol

There total 7 articles about (1S,2R,4S,6S)-6-Benzyloxy-2-(2-hydroxy-ethyl)-1-(2-phenyl-[1,3]dithian-2-ylmethyl)-2-triethylsilanyloxy-4-triisopropylsilanyloxy-cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 874349-97-0
(1S,2R,4S,6S)-6-Benzyloxy-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-(2-phenyl-[1,3]dithian-2-ylmethyl)-2-triethylsilanyloxy-4-triisopropylsilanyloxy-cyclohexanol

: 874350-04-6
(1S,2R,4S,6S)-6-Benzyloxy-2-(2-hydroxy-ethyl)-1-(2-phenyl-[1,3]dithian-2-ylmethyl)-2-triethylsilanyloxy-4-triisopropylsilanyloxy-cyclohexanol

Guidance literature:: With pyridine; pyridine hydrogenfluoride; In tetrahydrofuran; at 0 ℃; for 5h;
DOI:10.1002/chem.200500640

Reference yield:

: 874349-99-2
(1R,3S,5S)-1-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-methylene-5-triisopropylsilanyloxy-cyclohexane-1,3-diol

: 874350-04-6
(1S,2R,4S,6S)-6-Benzyloxy-2-(2-hydroxy-ethyl)-1-(2-phenyl-[1,3]dithian-2-ylmethyl)-2-triethylsilanyloxy-4-triisopropylsilanyloxy-cyclohexanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: 86 percent / NaH / dimethylformamide / 0 - 20 °C

2.1: 94 percent / 3-chloroperbenzoic acid; NaHCO₃ / CH₂Cl₂ / 2 h / 0 °C

3.1: 98 percent / Et₃N / CH₂Cl₂ / 2 h / 0 °C

4.1: n-BuLi / tetrahydrofuran; hexane / 2 h / -40 °C

4.2: tetrahydrofuran; hexane / 6 h / -40 °C

5.1: 524 mg / HF*pyridine; pyridine / tetrahydrofuran / 5 h / 0 °C

With pyridine; n-butyllithium; sodium hydride; sodium hydrogencarbonate; pyridine hydrogenfluoride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/chem.200500640

Reference yield:

: (4R,6S,8S)-8-Benzyloxy-4-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-triisopropylsilanyloxy-1-oxa-spiro[2.5]octan-4-ol

: 874350-04-6
(1S,2R,4S,6S)-6-Benzyloxy-2-(2-hydroxy-ethyl)-1-(2-phenyl-[1,3]dithian-2-ylmethyl)-2-triethylsilanyloxy-4-triisopropylsilanyloxy-cyclohexanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 98 percent / Et₃N / CH₂Cl₂ / 2 h / 0 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 2 h / -40 °C

2.2: tetrahydrofuran; hexane / 6 h / -40 °C

3.1: 524 mg / HF*pyridine; pyridine / tetrahydrofuran / 5 h / 0 °C

With pyridine; n-butyllithium; pyridine hydrogenfluoride; triethylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1002/chem.200500640