(S)-2-{2-[6-amino-7-chloro-3-(3,5-dimethylphenyl)-2-oxo-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(S)-2-{2-[6-amino-7-chloro-3-(3,5-dimethylphenyl)-2-oxo-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester
CAS No.:199942-75-1
Molecular Formula:C₂₉H₃₆ClN₃O₄
Molecular Weight:526.076
Hs Code.:
DSSTox Substance ID:DTXSID201101805

(S)-2-{2-[6-amino-7-chloro-3-(3,5-dimethylphenyl)-2-oxo-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester

Synonyms:SCHEMBL8145844;LBWXQYKOBUXKQI-FQEVSTJZSA-N;DTXSID201101805;(S)-2-{2-[6-amino-7-chloro-3-(3,5-dimethylphenyl)-2-oxo-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester;1,1-Dimethylethyl (2S)-2-[2-[[6-amino-7-chloro-3-(3,5-dimethylphenyl)-1,2-dihydro-2-oxo-4-quinolinyl]oxy]ethyl]-1-piperidinecarboxylate;199942-75-1

Suppliers and Price of (S)-2-{2-[6-amino-7-chloro-3-(3,5-dimethylphenyl)-2-oxo-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-2-{2-[6-amino-7-chloro-3-(3,5-dimethylphenyl)-2-oxo-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

XLogP3:5.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:525.2394343
Heavy Atom Count:37
Complexity:862

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=CC(=C1)C2=C(C3=CC(=C(C=C3NC2=O)Cl)N)OCCC4CCCCN4C(=O)OC(C)(C)C)C
Isomeric SMILES:CC1=CC(=CC(=C1)C2=C(C3=CC(=C(C=C3NC2=O)Cl)N)OCC[C@@H]4CCCCN4C(=O)OC(C)(C)C)C

Technology Process of (S)-2-{2-[6-amino-7-chloro-3-(3,5-dimethylphenyl)-2-oxo-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester

There total 14 articles about (S)-2-{2-[6-amino-7-chloro-3-(3,5-dimethylphenyl)-2-oxo-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: iron (III) chloride hexahydrate

: 199942-73-9
(S)-2-{2-[7-chloro-3-(3,5-dimethylphenyl)-6-nitro-2-oxo-1,2-dihydroquinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester

: 199942-75-1
(S)-2-{2-[6-amino-7-chloro-3-(3,5-dimethylphenyl)-2-oxo-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With hydrazine; In methanol; dichloromethane;

Reference yield:

: 26250-84-0
(S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid

: 199942-75-1
(S)-2-{2-[6-amino-7-chloro-3-(3,5-dimethylphenyl)-2-oxo-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

2: Ph₃P; DEAD / tetrahydrofuran

3: FeCl₃*6H₂O; NH₂NH₂ / methanol

With iron(III) chloride; triphenylphosphine; hydrazine; diethylazodicarboxylate; In tetrahydrofuran; methanol; 2: Mitsunobu alkylation / 3: Reduction;
DOI:10.1016/S0960-894X(00)00318-8

Reference yield:

: 199862-11-8
(S)-2-(diazoacetyl)piperidine-1-carboxylic acid tert-butyl ester

: 199942-75-1
(S)-2-{2-[6-amino-7-chloro-3-(3,5-dimethylphenyl)-2-oxo-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: silver benzoate / methanol; ethyl acetate; triethylamine

2: sodium hydroxide / diethyl ether; water

3: triphenylphosphine / tetrahydrofuran

4: hydrazine / methanol; dichloromethane

With sodium hydroxide; triphenylphosphine; hydrazine; silver benzoate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; ethyl acetate; triethylamine;