C₂₂H₁₈F₃NO₄

Base Information

Chemical Name:C₂₂H₁₈F₃NO₄
CAS No.:1427406-21-0
Molecular Formula:C₂₂H₁₈F₃NO₄
Molecular Weight:417.384
Hs Code.:

C<sub>22</sub>H<sub>18</sub>F<sub>3</sub>NO<sub>4</sub>

Synonyms:C₂₂H₁₈F₃NO₄

Suppliers and Price of C₂₂H₁₈F₃NO₄

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of C₂₂H₁₈F₃NO₄

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of C₂₂H₁₈F₃NO₄

There total 10 articles about C₂₂H₁₈F₃NO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1427407-46-2
C₂₄H₂₂F₃NO₄

: 1427406-21-0
C₂₂H₁₈F₃NO₄

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield:

: 83-40-9
3-methylsalicylic acid

: 1427406-21-0
C₂₂H₁₈F₃NO₄

Guidance literature:: Multi-step reaction with 10 steps

1.1: acetic acid; bromine / 24 h / 20 °C

2.1: potassium carbonate; caesium carbonate / N,N-dimethyl-formamide; acetone / 20 - 58 °C

3.1: water; sodium hydroxide / tetrahydrofuran / 5 h / 20 °C

4.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; ethanol; N,N-dimethyl-formamide / 100 °C

5.1: thionyl chloride / 6 h / 70 °C

6.1: sodium hydrogencarbonate / tetrahydrofuran / 2 h / 0 - 20 °C

7.1: borane-THF / tetrahydrofuran / 0 - 60 °C

8.1: caesium carbonate / acetone / 0.5 h / 20 °C

8.2: 1 h / 20 °C

9.1: aluminum (III) chloride; ethanethiol / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

10.1: lithium hydroxide; water / tetrahydrofuran / 3 h / 20 °C

With aluminum (III) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; borane-THF; water; bromine; sodium hydrogencarbonate; sodium carbonate; potassium carbonate; caesium carbonate; acetic acid; ethanethiol; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 722497-32-7
methyl 5-bromo-2-methoxy-3-methyl-benzoate

: 1427406-21-0
C₂₂H₁₈F₃NO₄

Guidance literature:: Multi-step reaction with 8 steps

1.1: water; sodium hydroxide / tetrahydrofuran / 5 h / 20 °C

2.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; ethanol; N,N-dimethyl-formamide / 100 °C

3.1: thionyl chloride / 6 h / 70 °C

4.1: sodium hydrogencarbonate / tetrahydrofuran / 2 h / 0 - 20 °C

5.1: borane-THF / tetrahydrofuran / 0 - 60 °C

6.1: caesium carbonate / acetone / 0.5 h / 20 °C

6.2: 1 h / 20 °C

7.1: aluminum (III) chloride; ethanethiol / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

8.1: lithium hydroxide; water / tetrahydrofuran / 3 h / 20 °C

With aluminum (III) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; borane-THF; water; sodium hydrogencarbonate; sodium carbonate; caesium carbonate; ethanethiol; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;