Multi-step reaction with 5 steps
1.1: triethylamine; isobutyl chloroformate / dichloromethane / 1 h / 0 - 20 °C
1.2: 6 h / 20 °C
2.1: 2,4,6-trimethyl-pyridine; 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere
3.1: dichloromethane / 0.5 h / 20 °C / Inert atmosphere
4.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere
5.1: sodium methylate / methanol / 24 h / 20 - 50 °C / Inert atmosphere
5.2: 50 °C / Inert atmosphere
With
2,4,6-trimethyl-pyridine; 1,3,5-trichloro-2,4,6-triazine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium methylate; triethylamine; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm2001053