Technology Process of (R)-2-(4-amino-4-carboxybutyl)benzoic acid
There total 6 articles about (R)-2-(4-amino-4-carboxybutyl)benzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: thionyl chloride / 14.5 h / -10 - 20 °C
2: N-ethyl-N,N-diisopropylamine; palladium diacetate / acetonitrile / 2 h / 130 °C / Microwave irradiation
3: 5%-palladium/activated carbon; hydrogen / methanol / 2 h
4: sodium hydroxide; water / methanol
5: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C
With
thionyl chloride; 5%-palladium/activated carbon; water; hydrogen; palladium diacetate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide;
In
methanol; dichloromethane; acetonitrile;
2: |Heck Reaction;
DOI:10.1016/j.bmcl.2014.02.058
- Guidance literature:
-
Multi-step reaction with 5 steps
1: chiral HPLC / hexane; isopropyl alcohol / Resolution of racemate
2: N-ethyl-N,N-diisopropylamine; palladium diacetate / acetonitrile / 2 h / 130 °C / Microwave irradiation
3: 5%-palladium/activated carbon; hydrogen / methanol / 2 h
4: sodium hydroxide; water / methanol
5: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C
With
5%-palladium/activated carbon; water; hydrogen; palladium diacetate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide;
In
methanol; hexane; dichloromethane; isopropyl alcohol; acetonitrile;
2: |Heck Reaction;
DOI:10.1016/j.bmcl.2014.02.058
