Technology Process of (3S)-3-methyl-4,4-bis(methoxycarbonyl)-5-phenylpentanoic acid
There total 3 articles about (3S)-3-methyl-4,4-bis(methoxycarbonyl)-5-phenylpentanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
chromium(VI) oxide; sulfuric acid;
In
acetone;
at 20 ℃;
for 1h;
DOI:10.1021/ja003774o
- Guidance literature:
-
Multi-step reaction with 2 steps
1: p-toluenesulfonic acid monohydrate / methanol / 10 h / 65 °C
2: 86 percent / CrO3; aq. H2SO4 / acetone / 1 h / 20 °C
With
chromium(VI) oxide; sulfuric acid; toluene-4-sulfonic acid;
In
methanol; acetone;
2: Jones oxidation;
DOI:10.1021/ja003774o
- Guidance literature:
-
Multi-step reaction with 3 steps
1: π-allylpalladium chloride dimer; (R,R)-1,2-di(2'-diphenylphosphinobenzamido)cyclohexane / tetrahydrofuran; various solvent(s) / 3 h / 25 °C
2: p-toluenesulfonic acid monohydrate / methanol / 10 h / 65 °C
3: 86 percent / CrO3; aq. H2SO4 / acetone / 1 h / 20 °C
With
chromium(VI) oxide; bis(η3-allyl-μ-chloropalladium(II)); sulfuric acid; toluene-4-sulfonic acid; (1R,2R)-1,2-bis[(2-diphenylphosphanyl)benzoylamino]cyclohexane;
In
tetrahydrofuran; methanol; acetone;
3: Jones oxidation;
DOI:10.1021/ja003774o
