6-bromo-N-(2-methyl-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)pyrazolo[1,5-a]pyridine-3-carboxamide

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Chemical Name:6-bromo-N-(2-methyl-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)pyrazolo[1,5-a]pyridine-3-carboxamide
CAS No.:1426531-12-5
Molecular Formula:C₂₈H₂₉BrN₆O₂
Molecular Weight:561.481
Hs Code.:

Synonyms:6-bromo-N-(2-methyl-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)pyrazolo[1,5-a]pyridine-3-carboxamide

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Chemical Property of 6-bromo-N-(2-methyl-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)pyrazolo[1,5-a]pyridine-3-carboxamide

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Technology Process of 6-bromo-N-(2-methyl-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)pyrazolo[1,5-a]pyridine-3-carboxamide

There total 2 articles about 6-bromo-N-(2-methyl-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)pyrazolo[1,5-a]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1211596-19-8
6-bromopyrazolo[1,5-a]pyridine-3-carboxylic acid

: 1426531-74-9
3-amino-4-methyl-N-(2-(4-methylpiperazin-1-yl)benzyl)benzamide

: 1426531-12-5
6-bromo-N-(2-methyl-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)pyrazolo[1,5-a]pyridine-3-carboxamide

Guidance literature:: 6-bromopyrazolo[1,5-a]pyridine-3-carboxylic acid; With thionyl chloride; at 60 ℃; for 1h;

3-amino-4-methyl-N-(2-(4-methylpiperazin-1-yl)benzyl)benzamide; With pyridine; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 655256-68-1
(2-(4-methylpiperazin-1-yl)phenyl)methanamine

: 18595-18-1
3-amino-4-methyl benzoic acid methyl ester

: 1426531-12-5
6-bromo-N-(2-methyl-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)pyrazolo[1,5-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine / toluene / Reflux

2.1: thionyl chloride / 1 h / 60 °C

2.2: 2 h / 20 °C / Inert atmosphere

With thionyl chloride; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; In toluene;

Reference yield:

: 1426531-12-5
6-bromo-N-(2-methyl-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)pyrazolo[1,5-a]pyridine-3-carboxamide

: 1426531-13-6
5-(1,5-dimethyl-2,4-dioxa-3-borabicyclo[3.1.0]hexan-3-yl)-1-methyl-1H-pyrazole

: 6-(1-methyl-1H-pyrazol-5-yl)-N-(2-methyl-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)pyrazolo[1,5-a]pyridine-3-carboxamide hydrochloride

Guidance literature:: 6-bromo-N-(2-methyl-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)pyrazolo[1,5-a]pyridine-3-carboxamide; 5-(1,5-dimethyl-2,4-dioxa-3-borabicyclo[3.1.0]hexan-3-yl)-1-methyl-1H-pyrazole; With caesium carbonate; In 1,2-dimethoxyethane; water;

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; water; at 100 ℃; Microwave irradiation;